Biomedizinische Analytiker:innen

Analyse von DNA-Polymorphismen (Short-Tandem-Repeat-Polymorphismen, Insertions-/Deletionspolymorphismen) in Klinik und Wissenschaft (DNA-Fragmentanalyse, DNA-Nukleotidsequenzierung, Real-time PCR)

Publications and Manuscripts (peer reviewed)

Dauber EM, Haas OA, Nebral K, Gassner C, Haslinger S, Geyeregger R, Hustinx H, Lejon Crottet S, Scharberg EA, Müller-Steinhardt M, Schönbacher M, Mayr WR, Körmöczi GF (2024) Body-wide chimerism and mosaicism are predominant causes of naturally occurring ABO discrepancies. Br J Haematol. 205 (3):1188–1196.

Rüger BM, Buchacher T, Dauber EM, Pasztorek M, Uhrin P, Fischer MB, Breuss JM, Leitner GC (2020) De novo Vessel Formation Through Cross-Talk of Blood-Derived Cells and Mesenchymal Stromal Cells in the Absence of Pre-existing Vascular Structures. Front. Bioeng. Biotechnol. 8:602210 (doi: 10.3389/fbioe.2020.602210)

Dauber EM, Kollmann D, Kozakowski N, Rasoul-Rockenschaub S, Soliman T, Berlakovich GA., Mayr WR (2020) Quantitative PCR of Indels to measure donor-derived cell-Free DNA – A potential method to detect acute rejection in kidney transplantation Transpl Int.33(3):298- 309 (doi: 10.1111/tri.13554. Epub 2019 Dec 13)

Eder M, Schwarz C, Kammer M, Jacobsen N, Stavroula ML, Cowan MJ, Chongkrairatanakul T, Gaston R, Ravanan R, Ishida H, Bachmann A, Alvarez S, Koch M, Garrouste C, Duffner UA, Cullis B, Schaap N, Medinger M, Sørensen SS, Dauber EM, Böhmig G, Regele H, Berlakovich GA, Wekerle T, Oberbauer R (2019) Allograft and patient survival after sequential HSCT and kidney transplantation from the same donor-A multicenter analysis. Am J Transplant 19(2):475-487 (doi: 10.1111/ajt.14970)

Dauber EM, Mayr WR, Hustinx H, Schönbacher M, Budde H, Legler TJ, König M, Haas OA, Fritsch G, Körmöczi GF (2019) Somatic mosaicisms of chromosome 1 at two different stages of ontogenetic development detected by Rh blood group discrepancies. Haematol 104(3):632- 638 (doi: 10.3324/haematol.2018.201293)

Dauber EM, Wenda S, Schwartz-Jungl EM, Glock B, Mayr WR (2016) Standardised genotyping of HLA STR by CE as surrogate for HLA class I and II markers and for identification of HLA identical siblings. Electrophoresis 37: 849-859  

Dauber EM, Wenda S, Schwartz-Jungl EM, Glock B, Mayr WR (2015) Sequence-based definition of eight short tandem repeat loci located within the HLA-region in an Austrian population. Forensic Sci Int Genet 14: 168-173  

Heinzl MW, Schönbacher M, Dauber EM, Panzer S, Mayr WR, Körmöczi GF (2015) Detection of granulocyte-reactive antibodies: a comparison of different methods. Vox Sang 108: 287-293

Schönbacher M, Heinzl MW, Dauber EM, Mayr WR, Panzer S, Körmöczi GF (2014) Granulocyte-reactive antibodies are associated with red blood cell alloimmunization. Vox Sang 107: 200-203 Dauber EM, Kratzer A, Neuhuber F, Parson W, Klintschar M, Bär W, Mayr WR (2012) Germline mutations of STR-alleles include multi-step mutations as defined by sequencing of repeat and flanking regions. Forensic Sci Int Genet 6: 381-386

Doxiadis GGM, de Groot N, Dauber EM, van Eede PH, Fae I, Faner R, Fischer G, Grubic Z, Lardy NM, Mayr W, Palou E, Swelsen W, Stingl K, Doxiadis IIN, Bontrop RE (2009) High resolution definition of HLA-DRB haplotypes by a simplified microsatellite typing technique. Tissue Antigens 74: 486-493

Körmöczi GF, Dauber EM, Haas OA, Legler TJ, Clausen FB, Fritsch G, Raderer M, Buchta C, Petzer AL, Schönitzer D, Mayr WR, Gassner C (2007) Mosaicism due to myeloid lineage- restricted loss of heterozygosity as cause of spontaneous Rh phenotype splitting. Blood 110: 2148-2157

Wegener R, Weirich V, Dauber EM, Mayr WR (2006) Mother-child exclusion due to paternal uniparental disomy 6. Int J Legal Med 120: 282-285

Schöniger-Hekele M, Müller C, Kramer L, Dauber E, Mayr WR, Wrba F, Rockenschaub S, Mühlbacher F (2006) Graft versus host disease after orthotopic liver transplantation documented by analysis of short tandem repeat polymorphisms. Digestion 74: 169-173

Wenda S, Dauber EM, Schwartz DW, Jungbauer C, Weirich V, Wegener R, Mayr WR (2005) ACTBP2 (alias ACTBP8) is localized on chromosome 6 (band 6q14). Forensic Sci Int 148: 207-209

Drexler C, Glock B, Vadon M, Staudacher E, Dauber EM, Ulrich S, Reisacher RBK, Mayr WR, Lanzer G, Wagner T (2005) Tetragametic chimerism detected in a healthy woman with mixed- field agglutination reactions in ABO blood grouping. Transfusion 45: 698-703

Klintschar M, Dauber EM, Ricci U, Cerri N, Immel UD, Kleiber M, Mayr WR (2004) Haplotype studies support slippage as the mechanism of germline mutations in short tandem repeats. Electrophoresis 25: 3344-3348

Wenda S, Dauber EM, Stadlbacher S, Glock B, Fischer M, Körmöczi GF, Mayr WR (2003) C2_4_4 microheterogeneity and HLA class I. Tissue Antigens 61: 484-486

Stadlbacher S, Dauber EM, Wenda S, Glock B, Hafner M, Körmöczi GF, Mayr WR (2003) The tetranucleotide repeat polymorphism C2_4_4: population data and linkage disequilibria with HLA class I. Immunobiology 207: 137-140 Gusmao L, Gonzalez-Neira A, Alves C, Sanchez-Diz P, Dauber EM, Amorim A, Carracedo A (2002) Genetic diversity of Y-specific STRs in chimpanzees (Pan troglodytes). Am J Primatol 57: 21-29

Dauber EM, Glock B, Schwartz DWM, Mayr WR (2000) Further sequence and length variation at the STR loci HumFES/FPS, HumVWA, HumFGA and D12S391. Int J Legal Med 113: 76- 80

Repas-Humpe LM, Humpe A, Lynen R, Glock B, Dauber EM, Simson G, Mayr WR, Köhler M, Eber S (1999) A dispermic chimerism in a 2-year-old Caucasian boy. Ann Hematol 78: 431- 434

Dauber EM, Glock B, Mayr D, Mayr WR (1999) A case of dispermic chimerism: Importance of DNA polymorphisms. J Biol Reg Homeos Ag 13: 51-53

Klintschar M, Glock B, Dauber EM, Mayr WR (1998) Genetic variation and sequence studies of a highly variable short tandem repeat at the D17S976 locus. Int Journal of Legal Med 112: 50-54

Glock B, Dauber EM, Schwartz DWM, Mayr WR (1997) Additional variability at the D12S391 STR locus in an Austrian population sample: sequencing data and allele distribution. Forensic Sci Int 90: 197-203

Glock B, Schwartz DWM, SchwartzJungl EM, Thorwartl GH, Dauber EM, Mayr WR (1997) A new allele at the short tandem repeat locus HumF13A01. Int J Legal Med 110: 284-285

Conference papers

Dauber EM, Mayr WR (2013) Noninvasive prenatal fetal genotyping from cell-free maternal plasma. Forensic Sci Int Genet Suppl 4: e226-e227

Dauber EM, Glock B, Mayr WR (2011) A primer binding site mutation at the D2S1338 locus resulting in a loss of amplification. Forensic Sci Int Genet Suppl 3: e87-e88

Dauber EM, Schwartz-Jungl EM, Wenda S, Dorner G, Glock B, Mayr WR (2009) Further allelic variation at the STR-loci ACTBP2 (SE33), D3S1358, D8S1132, D18S51 and D21S11. Forensic Sci Int Genet Suppl 2: 41-42

Dauber EM, Schwartz-Jungl EM, Wenda S, Dorner G, Glock B, Mayr WR (2009) A highly polymorphic STR-locus within the MHC-region close to HLA-DR/DQ: Austrian population data of DQIV (alias M2_4_32). Forensic Sci Int Genet Suppl 2: 355-356

Dauber EM, Dorner G, Wenda S, Schwartz-Jungl EM, Glock B, Bär W, Mayr WR (2008) Unusual FGA and D19S433 off-ladder alleles and other allelic variants at the STR loci D8S1132, vWA, D18S51 and ACTBP2 (SE33). Forensic Sci Int Genet Suppl 1: 109-111

Dauber EM, Glock B, Mayr WR (2008) Two examples of null alleles at the D19S433 locus due to the same 4 bp deletion in the presumptive primer binding site of the AmpFlSTR Identfiler kit. Forensic Sci Int Genet Suppl 1: 107-108  

Glock B, Dauber EM, Parson W, Schwartz-Jungl EM, Mayr WR (2008) A DYS438 null allele observed in two generations of a large family. Forensic Sci Int Genet Suppl 1: 206-207

Schwartz-Jungl EM, Dauber EM, Wenda S, Dorner G, Glock B, Mayr WR (2008) Multiplex PCR of three dinucleotide markers in the HLA class I region: D6S2792, D6S273 and D6S2972. Forensic Sci Int Genet Suppl 1: 370-372

Gourraud PA, Cambon-Thomsen A, Dauber EM, Feolo M, Hansen J, Mickelson E, Single RM, Thomsen M, Mayr WR (2007) Nomenclature for HLA microsatellites. Tissue Antigens 69 Suppl 1: 210-213

Dorner G, Dauber EM, Wenda S, Glock B, Mayr WR (2006) A triplex-PCR for SE33, D12S391 and D8S1132 and a singleplex-PCR for D6S389 in a single run. Int Congr Ser 1288: 418-420

Dauber EM, Parson W, Glock B, Mayr WR (2006) Two apparent mother/child mismatches due to mispriming at the D3S1358 and the SE33 (ACTBP2) locus. Int Congr Ser 1288: 456-458

Dauber EM, Dorner G, Mitterbauer M, Wenda S, Fae I, Glock B, Mayr WR (2004) Discrepant results of samples taken from different tissues of a single individual. Int Congr Ser 1261: 48- 49

Wenda S, Dauber EM, Stadlbacher S, Glock B, Dorner G, Mayr WR (2004) Multiplex PCR investigation of the STR loci C1_4_4, C2_4_4 and C3_3_6 in the HLA class I region. Int Congr Ser 1261: 188-190

Dauber EM, Bar W, Klintschar M, Neuhuber F, Parson W, Mueller-van der Spruit E, Mayr WR (2004) New sequence data of allelic variants at the STR loci ACTBP2 (SE33), D21S11, FGA, vWA, CSF1PO, D2S1338, D16S539, D18S51 and D19S433 in Caucasoids. Int Congr Ser 1261: 191-193

Reisacher RBK, Glock B, Rennhofer SO, Dauber EM, Wenda S, Tröscher D, Huttler C, Dillinger AM, Dorner G, Mayr WR (2004) Short tandem repeat polymorphisms across the HLA- complex: sequence and population data of D6S389 and D6S1051. Int Congr Ser 1261: 236- 238

Dauber EM, Wenda S, Glock B, Dorner G, Mayr WR (2004) Mosaicism as a possible reason for poor amplification of amelogenin-Y in three human male individuals. Int Congr Ser 1261: 508-510

Dauber EM, Bär W, Klintschar M, Neuhuber F, Parson W, Glock B, Mayr WR (2003) Mutation rates at 23 different short tandem repeat loci. Int Congr Ser 1239: 565-567

Dauber EM, Fae I, Stadlbacher S, Glock B, Schwartz DWM, Mayr WR (2003) STR typing in a pair of chimeric twins. Int Congr Ser 1239: 569-571

Glock B, Reisacher RBK, Rennhofer SO, Tröscher D, Dauber EM, Mayr WR (2003) Evaluation of Powerplex™16 for typing of degraded DNA samples. Int Congr Ser 1239: 609-611

Glock B, Wagner T, Dauber EM, Reisacher RBK, Stadlbacher S, Tröscher D, Rennhofer SO, Lanzer G, Mayr WR (2003) Investigation of chimerism in a healthy, adult female by means of minisatellite and microsatellite typing. Int Congr Ser 1239: 561-563

Stadlbacher S, Dauber EM, Glock B, Mayr WR (2003) SE33 (HumACTBP2): Native gel electrophoresis versus denaturing capillary electrophoresis, and population data. Int Congr Ser 1239: 699-701

Dauber EM, Dorner G, Stadlbacher S, Glock B, Schwartz DWM, Mayr WR (2000) Denaturing versus non-denaturing electrophoresis for D21S11 and additional sequence and population data. Prog Forensic Genet8: 148-150

Glock B, Dauber EM, Schwartz DWM, Mayr WR (2000) Identity testing on retention samples of blood donations: A methodical approach. Prog Forensic Genet 8: 479-481

Glock B, Dauber EM, Schwartz DWM, Stadlbacher S, Eder G, Mayr WR (2000) STR locus D8S1132: Population and sequencing studies in Austrian Caucasoids and pan troglodytes. Prog Forensic Genet 8: 145-147

Dauber EM, Glock B, Schwartz DWM, Mayr WR (2000) Mutational events at human micro- and minisatellite loci: Mutation rates and new STR-alleles. Prog Forensic Genet 8: 21-23

Dauber EM, Glock B, Schwartz DWM, Mayr WR (1998) Sequencing and population data of a short tandem repeat locus in the human alpha fibrinogen gene (HumFGA) in an Austrian population sample. Prog Forensic Genet 7 Int Congr Ser 1167: 264-266  

Glock B, Schwartz DWM, Dauber EM, Schwartz-Jungl EM, Mayr WR (1998) Austrian population data on the polymorphic STR loci DYS19 and HumF13B. Prog Forensic Genet 7 Int Congr Ser 1167: 291-293

Klintschar M, Glock B, Dauber EM, Mayr WR (1998) Allele frequencies and sequence studies of a highly variable STR at the D17S3976 locus. Prog Forensic Genet 7 Int Congr Ser 1167: 303-305

Glock B, Dauber EM, Schwartz DWM, Mayr WR (1998) Comparative investigation of the STR polymorphism at locus D12S391 in an Austrian population sample: Additional sequence data and allele distribution. Prog Forensic Genet 7 Int Congr Ser 1167: 512-514

Glock B, Schwartz DWM, Dauber EM, SchwartzJungl EM, Mayr WR (1996) AMPFLP-typing for the HUMCD4 STR polymorphism in an Austrian caucasoid population sample: Sequence data and allele distribution. Adv Foren H 6: 55-57

Glock B, Schwartz DWM, Dauber EM, SchwartzJungl EM, Mayr WR (1996) Investigation of the STR HumLIPOL in Austrian Caucasoid individuals: Sequence data and allele frequencies. Adv Foren H 6: 66-68

Schwartz DWM, Dauber EM, Glock B, Mayr WR (1996) AMPFLP-typing of the D21S11 microsatellite polymorphism: Allele frequencies and sequencing data in the Austrian population. Adv Foren H 6: 622-625

Schwartz DWM, Dauber EM, Glock B, Mayr WR (1996) Typing of the HUMVWA microsatellite polymorphism: Allele frequencies and sequencing data. Adv Foren H 6: 58-59

Schwartz DWM, Glock B, Dauber EM, Schwartz-Jungl EM, Mayr WR (1996) Typing for the HumFES/FPS short tandem repeat polymorphism in an Austrian Caucasoid population sample. Adv Foren H 6: 626-627

Abstracts

Dauber EM, Speckl H, Roch FF, Rosenmayr A, Panzer S, Leitner G, Mayr WR (2019) Inference of HLA-DRB1 by flanking microsatellites D6S273 AND DQIV. Abstracts of the 33^rd European Immunogenetics and Histocompatibility Conference, Lisbon, Portugal, May 8- 11, 2019. HLA 93(5):347-8

Dauber EM, Speckl H, Roch FF, Rosenmayr A, Panzer S, Leitner G, Mayr WR (2019) Linkage disequilibria of STR alleles and haplotypes with HLA in Central European and Turkish stem cell donors. Abstracts of the 33rd European Immunogenetics and Histocompatibility Conference, Lisbon, Portugal, May 8- 11, 2019. HLA 93(5):347

Kollmann D, Dauber EM, Fischer GF, Soliman T, Berlakovich G, Mayr WR (2017) Cell-free donor DNA circulating in recipient plasma: indel-polymorphisms as non-invasive marker for acute rejection in kidney transplantation. Abstracts of the 18th Congress of the European Society for Organ Transplantation, Barcelona, Spain. Transplant International 16 (suppl 2): 111.

Schwarz C, Lawitschka A, Böhmig GA, Dauber E, Greinix H, Kozakowski N, Mühlbacher F, Berlakovich G, Wekerle T (2016) Three-Year Outcome After HSCT with Subsequent KT from the Same Haploidentical Donor without Immunosuppression Abstracts of the American Transplant Congress, Boston, USA, Jun 11- 15, 2016. Am J Transplant. 2016; 16 (suppl 3): 727.

Dauber EM, Wenda S, Mayr WR (2014) Sequenced Allelic Ladders obtained from IHWG Samples for a Standardised Genotyping of HLA-Microsatellites. Tissue Antigens 84: 59-60

Dauber EM, Mayr WR (2014) Austrian sequence and population data of the dinucleotide short tandem repeat polymorphism D6S2789 (TNFd) located in the HLA class III region. Tissue Antigens 84: 60-61  

Schwarz C, Lawitschka A, Böhmig GA, Dauber EM, Greinix H, Kozakowski N, Berlakovich G, Mühlbacher F, Wekerle T (2013) Kidney transplantation following HSCT from the same haploidentical donor without immunosuppression - a case report. Transplant International 26: 33-33

Ulrich S, Dauber EM, Posch U, Steitzer HJ, Lanzer G, Mayr WR (2013) Suspected unequal crossing over on short arm of chromosome 6-a case report. Tissue Antigens 81: 357-358

Dauber EM, Schwartz-Jungl E, Wenda S, Glock B, Fischer G, Mayr WR (2012) HLA-linked Microsatellites. Tissue Antigens 79: 479-480

Dauber EM, Wenda S, Schwartz-Jungl E, Glock B, Mayr WR (2012) Application of a recommended nomenclature to the HLA microsatellite loci D6S2972, D6S2792 (Tnfa), D6S273 and DQIV. Tissue Antigens 79: 483-484

Doxiadis GG, de Groot N, Dauber EM, van Eede PH, Fae I, Faner R, Fischer G, Grubic Z, Lardy N, Mayr W, Palou E, Swelsen W, Stingl K, Doxiadis II, Bontrop RE (2010) A simplified microsatellite typing technique for high resolution HLA-DRB haplotyping allows the localization of DRB genes. Tissue Antigens 75: 518-518

Burgasser G, Dauber EM, Huber A, Thaler A (2000) Discordant manifestation of Retraction Syndrome (Stilling-Tuerk-Duane) in homocygote twins. Invest Ophth Vis Sci 41: S708-S708

Presentations (selected)

Y-STR profiles detectable in female recipient’s plasma after kidney transplantations from male donors. EM Dauber, D Kollmann, G Berlakovich, WR Mayr (2019) 28th Congress of the International Society of Forensic Genetics, Prague, Czech Republic

A genetic inconsistency at the D7S820 locus-multistep mutation, uniparental disomy or other? EM Dauber, B Glock, WR Mayr, 26th International Congress of the International Society for Forensic Genetics, Krakow, Poland, 2015 (poster)

Sequenced allelic ladders obtained from IHWG samples for standardised genotyping of HLA- microsatellites. EM Dauber, S Wenda, WR Mayr. 28th European Immunogenetics and Histocompatibility Conference, EFI Stockholm, Sweden, 2014 (poster)

Austrian sequence and population data of the dinucleotide short tandem repeat polymorphism D6S2789 (TNFd) located in the HLA Class III region. EM Dauber, WR Mayr. 28th European Immunogenetics and Histocompatibility Conference, EFI Stockholm, Sweden, 2014 (poster)

Discrepant results of non-invasive prenatal RHD testing and serology cleared up by sequencing. Dauber EM, Newesely-Meyer M, Mühlbacher A, Utz I, Schönbacher M, Mayr WR, Körmöczi GF. 45th Annual Congress of the German Society of Transfusion Medicine and Immunohematology (DGTI), Graz, Austria, 2012 (poster)

HLA-linked microsatellites -is prediction of HLA-haplotypes possible? EM Dauber, EM Schwartz-Jungl, S Wenda, B Glock, G Fischer, WR Mayr. 26th European Immunogenetics and Histocompatibility Conference, EFI and 23rd Annual Meeting of the British Society for Histocompatibility and Immunogenetics, BSHI Liverpool, United Kingdom, 2012 (poster)

Application of a recommended nomenclature to the HLA microsatellite loci D6S273, D6S2972, D6S2792 (TNFa), and DQIV. EM Dauber, S Wenda, EM Schwartz-Jungl, B Glock, WR Mayr. 26th European Immunogenetics and Histocompatibility Conference, EFI and 23rd Annual Meeting of the British Society for Histocompatibility and Immunogenetics, BSHI Liverpool, United Kingdom, 2012 (poster)

A primer binding site mutation at the D2S1338 locus resulting in a loss of amplification EM Dauber, B Glock, WR Mayr. 24th International Congress, International Society for Forensic Genetics, Vienna, Austria, 2011 (poster)

Rare genetic phenomena can cause problems in HLA-typing. EM Dauber, S Wenda, WR Mayr, 18. Jahrestagung der Deutschen Gesellschaft für Immungenetik, Wien, 2010 (oral)

A highly polymorphic STR-locus within the MHC-region close to HLA-DR/DQ: Austrian population data of DQIV (alias M2_4_32). EM Dauber, EM Schwartz-Jungl, S Wenda, G Dorner, B Glock, WR Mayr. 23rd International Congress, International Society for Forensic Genetics, Buenos Aires, Argentina, 2009 (poster)

Multiplex PCR of three dinucleotide markers in the HLA Class I Region: D6S2792 (TNFa), D6S273 and D6S2972. EM Schwartz-Jungl, EM Dauber, S Wenda, G Dorner, B Glock, WR Mayr. 22nd International Congress, International Society for Forensic Genetics, Copenhagen, Denmark, 2007 (poster)

Discrepant results of samples taken from different tissues of a single individual. EM Dauber, G. Dorner, M. Mitterbauer, S. Wenda, I. Faé, B. Glock, W.R. Mayr, 20th International Congress, International Society for Forensic Haemogenetics, Arcachon, 2003 (oral)

STR-typing in a pair of chimeric twins. EM Dauber, I Faé, S Stadlbacher, B Glock, DWM Schwartz and WR Mayr. 19th International Congress, International Society for Forensic Haemogenetics, Münster, Germany, 2001 (oral)

Mutation rates at twenty-three different short tandem repeat loci. EM Dauber, W Bär, M Klintschar, F Neuhuber, W Parson, B Glock, WR Mayr 19th International Congress, International Society for Forensic Haemogenetics, Münster, Germany, 2001 (oral)

Mutational events at human micro- and minisatellite loci: mutation rates and new STR-alleles. EM Dauber, B Glock, DWM Schwartz, WR Mayr. 18th International Congress, International Society for Forensic Haemogenetics, San Francisco, 1999 (oral)

A case of dispermic chimerism: importance of DNA polymorphisms. EM Dauber, B Glock, J Neumuller, D Mayr, WR Mayr. Second European Symposium on Human Identification, Promega Corporation, Innsbruck, Austria, 1998 (poster)

Sequencing and population data of a short tandem repeat locus in the human alpha fibrinogen gene (HumFGA) in an Austrian population sample. EM Dauber, B Glock, DWM Schwartz, WR Mayr. 17th International Congress, International Society for Forensic Haemogenetics, Oslo, Norway, 1997 (poster)

Ausbildung

• geb. 1964 in Wien
• 1982 Matura (Reifeprüfung) mit Auszeichnung am BG Bruck/Mur
• 1982 Auslandspraktikum Exeter/GB
• 1985 Diplom für Medizinisch-Technischen Laboratoriumsdienst (Bachelor-äquivalent)
• 1997 Sonderausbildung (gem. §32 MTD-Gesetz, BGBl. 460/1992) zur Heranbildung von leitenden Angehörigen der medizinisch-technischen Dienste
• 2010 Master of Science in Biomedical Science
• 2016 Doktorat der angewandten medizinischen Wissenschaften

Berufserfahrung

• 01-08/1986 Virologische Forschung, Forschungszentrum Orth/Donau, Fa. Immuno AG (später Baxter, bzw. Takeda)
• 09/1986-03/1991 Blutspendezentrale für Wien, NÖ, Bgld, Österreichisches Rotes Kreuz, Wien
• 04/1991-12/1993 Institut für Blutgruppenserologie, AKH Wien
• seit 01/1994 Univ.klinik für Blutgruppenserologie und Transfusionsmedizin, Medizinische Universität Wien
• seit 08/1998 Leitende Biomedizinische Analytikerin (gem. Bescheid vom 16.7.1998 Überstellung in K/K1)

Speiser P, Fischer G, Pickl WF, Fae I, Pausch V, Kribitz M. [Usefulness and cogency of gene probes in paternity questions (Personal experiences: 1989/90]. Wien Klin Wochenschr. 1990;102:673-676.

Fischer GF, Fae I, Valent P, Pickl WF. [The use of highly polymorphic DNA systems in the demonstration of mixed chimerism following bone marrow transplantation]. Wien Klin Wochenschr. 1991;103:152-154.

Fischer GF, Pickl WF, Fae I, Pausch V, Speiser P. Elucidation of apparent non-maternity with DNA probes detecting highly polymorphic single locus systems. Vox Sang. 1991;60:181-183.

Pickl WF, Fischer GF, Fae I, Speiser P. [Identification of an old frozen alcohol blood sample using a genetic probe technique]. Wien Klin Wochenschr. 1991;103:155-157.

Smrzka OW, Fae I, Pickl WF, Fischer GF. HLA-DRB3 typing by restriction digestion of locus-specific amplified DNA. Tissue Antigens. 1991;37:205-210.

Fischer GF, Fae I, Dub E, Pickl WF. Analysis of the gene polymorphism of ABO blood group specific transferases helps diagnosis of acquired B status. Vox Sang. 1992;62:113-116.

Fischer GF, Fae I, Pickl WF. Distribution of polymorphic HLA-DR and -DQ alleles as determined by restriction fragment length polymorphism analysis in an Austrian population. Vox Sang. 1992;62:236-241.

Fischer GF, Pickl WF, Fae I, et al. Association between IgE response against Bet v I, the major allergen of birch pollen, and HLA-DRB alleles. Hum Immunol. 1992;33:259-265.

Maurer D, Fischer GF, Fae I, et al. IgM and IgG but not cytokine secretion is restricted to the CD27+ B lymphocyte subset. J Immunol. 1992;148:3700-3705.

Mytilineos J, Scherer S, Trejaut J, et al. Analysis of discrepancies between serologic and DNA-RFLP typing for HLA-DR in kidney graft recipients. Transplant Proc. 1992;24:2478-2479.

Fischer GF, Fae I, Pickl WF. The HLA-DRB6*0201 allele of a pseudogene commonly associated with HLA-DR2 specificities is present in an HLA-DRB1*0101-DRB5*0101 haplotype. Immunogenetics. 1993;37:285-287.

Mytilineos J, Scherer S, Dunckley H, et al. DNA HLA-DR typing results of 4000 kidney transplants. Transplantation. 1993;55:778-781.

Mytilineos J, Scherer S, Dunckley H, et al. DNA typing of 3500 cadaver kidney transplants does not confirm the "DR6 effect". Transplant Proc. 1993;25:207-209.

Opelz G, Mytilineos J, Scherer S, et al. Analysis of HLA-DR matching in DNA-typed cadaver kidney transplants. Transplantation. 1993;55:782-785.

Pickl WF, Fae I, Fischer GF. Detection of established and novel alleles of the HLA-DPB1 locus by PCR-SSO. Vox Sang. 1993;65:316-319.

Pickl WF, Fischer GF, Fae I, Kolarz G, Scherak O. HLA-DR1-positive patients suffering from rheumatoid arthritis are at high risk for developing mucocutaneous side effects upon gold therapy. Hum Immunol. 1993;38:127-131.

Pickl WF, Majdic O, Fae I, Reuschel R, Holter W, Knapp W. The soluble pool of beta 2-microglobulin free HLA class I alpha-chains. Qualitative and quantitative characterization. J Immunol. 1993;151:2613-2622.

Berger J, Molzer B, Fae I, Bernheimer H. X-linked adrenoleukodystrophy (ALD): a novel mutation of the ALD gene in 6 members of a family presenting with 5 different phenotypes. Biochem Biophys Res Commun. 1994;205:1638-1643.

Fischer GF, Pickl WF, Fae I, Anegg B, Milota S, Volc-Platzer B. Association between chronic cutaneous lupus erythematosus and HLA class II alleles. Hum Immunol. 1994;41:280-284.

Moser R, Fae I, Neumeister A, Pober M, Mutz I, Panzer S. Neonatal allo-immune thrombocytopenia due to fetomaternal HPA-1 incompatibility of a homozygous HPA-1a mother and a homozygous HPA-1b father. A case report. Eur J Pediatr. 1994;153:95-97.

Berger J, Bernheimer H, Fae I, et al. Association of X-linked adrenoleukodystrophy with HLA DRB1 alleles. Biochem Biophys Res Commun. 1995;216:447-451.

Fischer GF, Fae I, Petrasek M, Haas H, Mayr WR. An HLA-DR11 variant (HLA-DRB1*1115) segregating in a family of Turkish origin. Tissue Antigens. 1995;45:143-144.

Fischer GF, Fae I, Petrasek M, Moser S. A combination of two distinct in vitro amplification procedures for DNA typing of HLA-DRB and -DQB 1 alleles. Vox Sang. 1995;69:328-335.

Smrzka OW, Fae I, Stoger R, et al. Conservation of a maternal-specific methylation signal at the human IGF2R locus. Hum Mol Genet. 1995;4:1945-1952.

Berger J, Gmach M, Fae I, Molzer B, Bernheimer H. A new polymorphism of arylsulfatase A within the coding region. Hum Genet. 1996;98:348-350.

Fischer GF, Fae I, Moser S, et al. Ligation based HLA-B*27 typing. Tissue Antigens. 1996;48:148-152.

Fischer GF, Broer E, Fae I, Leitner D, Mayr WR. Nucleotide sequence analysis of an HLA-B47 variant (HLA-B*4702). Tissue Antigens. 1997;49:540-542.

Pickl WF, Majdic O, Fischer GF, et al. MUC18/MCAM (CD146), an activation antigen of human T lymphocytes. J Immunol. 1997;158:2107-2115.

Fischer G, Kreuzer D, Beer U, Gleissner B, Wasilewski K, Fae I. The sixth quality control exercise of the Central European tissue typing laboratories. Bone Marrow Transplant. 1998;22 Suppl 4:S14-16.

Fischer GF, Fae I, Frey E, Mayr WR. HLA-A*02172* adds to the heterogeneity of HLA-A*02 alleles. Tissue Antigens. 1998;51:312-314.

Drabek J, Bunce M, Fae I, et al. Characterization of a novel HLA-A*24 allele containing an HLA-A*03 sequence motif. Tissue Antigens. 1999;54:98-101.

Fae I, Gleissner B, Kriks D, Leitner D, Fischer GF. Serological and nucleotide sequence analysis of HLA-A*6812. Tissue Antigens. 2000;56:276-278.

Fischer GF, Fae I, Mann D, et al. An HLA class-II allele frequent in Eskimos and Amerindians is found in the Tyrolean Ice Man. Ann Hum Genet. 2001;65:363-369.

Danzer M, Leitner D, Gangl E, Fae I, Fischer GF, Gabriel C. A novel HLA-DRB1*13 allele (DRB1*1357) identified by polymerase chain reaction with sequence-specific primers and direct sequencing. Tissue Antigens. 2004;64:213-214.

Fae I, Lau M, Voorter C, Mayr WR, Fischer GF. HLA-B*8102*, a new allele found in an external proficiency testing scheme. Tissue Antigens. 2004;64:608-610.

Loewe R, Kittler H, Fischer G, Fae I, Wolff K, Petzelbauer P. BRAF kinase gene V599E mutation in growing melanocytic lesions. J Invest Dermatol. 2004;123:733-736.

Greinix HT, Fae I, Schneider B, et al. Impact of HLA class I high-resolution mismatches on chronic graft-versus-host disease and survival of patients given hematopoietic stem cell grafts from unrelated donors. Bone Marrow Transplant. 2005;35:57-62.

Jahn-Schmid B, Fischer GF, Bohle B, et al. Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 *01. J Allergy Clin Immunol. 2005;115:399-404.

Mrazek F, Fae I, Ambruzova Z, et al. A novel HLA-B*420502 allele identified by PCR-SSO/SSP routine typing and confirmed by Sequencing-based typing. Tissue Antigens. 2005;65:275-277.

Danzer M, Polin H, Fae I, Fischer GF, Gabriel C. Exon 1-4 sequence analysis of a novel HLA-A allele, HLA-A*2458. Tissue Antigens. 2006;68:177-178.

Ludajic K, Fae I, Fischer GF. Characterization of a new HLA-DPB1 allele, DPB1*010103. Tissue Antigens. 2006;67:255-256.

Mrazek F, Fae I, Ambruzova Z, et al. A single amino acid exchange shifts the serological reactivity of the novel HLA-B*4442 allele product from HLA-B44 to HLA-B21. Int J Immunogenet. 2006;33:197-200.

Vidan-Jeras B, Kunilo S, Fae I, Kandus A, Fischer GF. A novel HLA-B*2730 allele found in a Slovene patient affected with IgA nephropathy. Int J Immunogenet. 2006;33:371-373.

Danzer M, Polin H, Proll J, et al. High-throughput sequence-based typing strategy for HLA-DRB1 based on real-time polymerase chain reaction. Hum Immunol. 2007;68:915-917.

Vidan-Jeras B, Ambroz N, Fae I, Kemperle I, Fischer G. HLA-B*350802, a novel allele, which has arisen by silent mutation at codon 67. Tissue Antigens. 2007;69:363.

Ludajic K, Balavarca Y, Bickeboller H, et al. Impact of HLA-DPB1 allelic and single amino acid mismatches on HSCT. Br J Haematol. 2008.

Faé I, Rosenmayr A, Mayr WR, Fischer GF. A novel HLA-C allele, Cw*0617. Tissue Antigens. 2008 Nov;72(5):499-500.

Ludajic K, Balavarca Y, Bickeböller H, Rosenmayr A, Fae I, Fischer GF, Kouba M, Pohlreich D, Kalhs P, Greinix HT. KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation. Bone Marrow Transplant. 2009 Jul;44(2):97-103.

Doxiadis GG, de Groot N, Dauber EM, van Eede PH, Fae I, Faner R, Fischer G, Grubic Z, Lardy NM, Mayr W, Palou E, Swelsen W, Stingl K, Doxiadis II, Bontrop RE. High resolution definition of HLA-DRB haplotypes by a simplified microsatellite typing technique. Tissue Antigens. 2009 Dec;74(6):486-93

Ludajic K, Balavarca Y, Bickeböller H, Rosenmayr A, Fischer GF, Faé I, Kalhs P, Pohlreich D, Kouba M, Dobrovolna M, Greinix HT. Minor ABO-mismatches are risk factors for acute graft-versus-host disease in hematopoietic stem cell transplant patients. Biol Blood Marrow Transplant. 2009 Nov;15(11):1400-6.

Ludajic K, Rosenmayr A, Faé I, Fischer GF, Balavarca Y, Bickeböller H, Kalhs P, Greinix HT. Association of HLA-E polymorphism with the outcome of hematopoietic stem-cell transplantation with unrelated donors. Transplantation. 2009 Nov 27;88(10):1227-8.

Garritsen HS, Fae I, Legath N, Hannig H, Fischer GF. Identification of a novel HLA-DRB3*01 variant, HLA-DRB3*0114, containing a DRB1 sequence motif by micro-temperature gradient gel electrophoresis confirmed by sequence-based typing. Tissue Antigens. 2010 Feb;75(2):185-6.

Rosenmayr A, Pointner-Prager M, Mitterschiffthaler A, Bozic L, Pelzmann B, Tüchler H, Fae I, Fischer GF, Greinix HT, Peters Ch, Kalhs P, Krieger O, Linkesch W, Nachbaur D, Urban Ch, Posch U, Lanzer G, Gabriel Ch, Schennach H, Mayr WR. What are a patient's current chances of finding a matched unrelated donor? Twenty years' central search experience in a small country. Bone Marrow Transplant. 2012 Feb;47(2):172-80

Chen KW, Focke-Tejkl M, Blatt K, Kneidinger M, Gieras A, Dall'Antonia F, Faé I, Fischer G, Keller W, Valent P, Valenta R, Vrtala S. Carrier-bound nonallergenic Der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients. Allergy. 2012 May;67(5):609-21.

Rosenmayr A, Pointner-Prager M, Winkler M, Mitterschiffthaler A, Pelzmann B, Bozic L, Pichler SK, Tüchler H, Fae I, Fischer G. The Austrian Bone Marrow Donor Registry: Providing Patients in Austria with Unrelated Donors for Transplant - a Worldwide Cooperation. Transfus Med Hemother. 2011 Oct;38(5):292-299.

Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background. Knapp B, Fischer G, Van Hemelen D, Fae I, Maillere B, Ebner C, Schreiner W, Bohle B, Jahn-Schmid B. BMC Immunol. 2012 Aug 8;13:43.

Gonzalez-Galarza FF, Mack SJ, Hollenbach J, Fernandez-Vina M, Setterholm M, Kempenich J, Marsh SG, Jones AR, Middleton D; HLA Rare Allele Consortium. 16(th) IHIW: extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles. Int J Immunogenet. 2013 Feb;40(1):60-5.

Hollenbach JA, Augusto DG, Alaez C, Bubnova L, Fae I, Fischer G, Gonzalez-Galarza FF, Gorodezky C, Karabon L, Kusnierczyk P, Noble J, Rickards O, Roberts C, Schaffer M, Shi L, Tavoularis S, Trachtenberg E, Yao Y, Middleton D. 16(th) IHIW: population global distribution of killer immunoglobulin-like receptor (KIR) and ligands. Int J Immunogenet. 2013 Feb;40(1):39-45.

Wenda S, Faé I, Sanchez-Mazas A, Nunes JM, Mayr WR, Fischer GF. The distribution of MICA alleles in an Austrian population: evidence for increasing polymorphism. Hum Immunol. 2013 Oct;74(10):1295-9.

Gabriel C, Fürst D, Faé I, Wenda S, Zollikofer C, Mytilineos J, Fischer GF. HLA typing by next-generation sequencing - getting closer to reality. Tissue Antigens. 2014 Feb;83(2):65-75.

Schwaiger J, Aberle JH, Stiasny K, Knapp B, Schreiner W, Fae I, Fischer G, Scheinost O, Chmelik V, Heinz FX. Specificities of human CD4+ T cell responses to an inactivated flavivirus vaccine and infection: correlation with structure and epitope prediction. J Virol. 2014 Jul;88(14):7828-42

Wendt J, Rauscher S, Burgstaller-Mühlbacher S, Roka F, Fae I, Fischer G, Pehamberger H, Okamoto I. Actinic damage on the back is significantly determined by MC1R variants and previous sun exposure compared with other body sites in a multivariate analysis. Br J Dermatol. 2014 Sep;171(3):622-30.

Van Hemelen D, Mahler V, Fischer G, Fae I, Reichl-Leb V, Pickl W, Jutel M, Smolinska S, Ebner C, Bohle B, Jahn-Schmid B. HLA class II peptide tetramers vs allergen-induced proliferation for identification of allergen-specific CD4 T cells. Allergy. 2015 Jan;70(1):49-58.

Kitzmüller C, Zulehner N, Roulias A, Briza P, Ferreira F, Faé I, Fischer GF, Bohle B. Correlation of sensitizing capacity and T-cell recognition within the Bet v 1 family. J Allergy Clin Immunol. 2015 Jul;136(1):151-8.

Wendt J, Rauscher S, Burgstaller-Muehlbacher S, Fae I, Fischer G, Pehamberger H, Okamoto I. Human Determinants and the Role of Melanocortin-1 Receptor Variants in Melanoma Risk Independent of UV Radiation Exposure. JAMA Dermatol. 2016 Jul 1;152(7):776-82.

Müller C, Wendt J, Rauscher S, Burgstaller-Muehlbacher S, Sunder-Plassmann R, Scheurecker C, Richtig E, Fae I, Fischer G, Pehamberger H, Okamoto I. Characterization of patients at high risk of melanoma in Austria. Br J Dermatol. 2016 Jun;174(6):1308-17.

Koblischke M, Mackroth MS, Schwaiger J, Fae I, Fischer G, Stiasny K, Heinz FX, Aberle JH. Protein structure shapes immunodominance in the CD4 T cell response to yellow fever vaccination. Sci Rep. 2017 Aug 21;7(1):8907

Wenda S, Faé I, Fischer GF. An HLA-B7-specific antibody in an HLA-B*07 positive patient explained by a nonexpressed allele (HLA-B*07:181N). HLA. 2017 Jul;90(1):32-35.

Voorter CEM, Matern B, Tran TH, Fink A, Vidan-Jeras B, Montanic S, Fischer G, Fae I, de Santis D, Whidborne R, Andreani M, Testi M, Groeneweg M, Tilanus MGJ. Full-length extension of HLA allele sequences by HLA allele-specific hemizygous Sanger sequencing (SSBT). Hum Immunol. 2018 Nov;79(11):763-772.

Wendt J, Mueller C, Rauscher S, Fae I, Fischer G, Okamoto I. Contributions by MC1R Variants to Melanoma Risk in Males and Females. JAMA Dermatol. 2018 Jul 1;154(7):789-795

Askar M, Madbouly A, Zhrebker L, Willis A, Kennedy S, Padros K, Rodriguez MB, Bach C, Spriewald B, Ameen R, Shemmari SA, Tarassi K, Tsirogianni A, Hamdy N, Mossallam G, Hönger G, Spinnler R, Fischer G, Fae I, Charlton R, Dunk A, Vayntrub TA, Halagan M, Osoegawa K, Fernández-Viña M. HLA Haplotypes In 250 Families: The Baylor Laboratory Results And A Perspective On A Core NGS Testing Model For The 17th International HLA And Immunogenetics Workshop. Hum Immunol. 2019 Nov;80(11):897-905.

Schischlik F, Jäger R, Rosebrock F, Hug E, Schuster M, Holly R, Fuchs E, Milosevic Feenstra JD, Bogner E, Gisslinger B, Schalling M, Rumi E, Pietra D, Fischer G, Faé I, Vulliard L, Menche J, Haferlach T, Meggendorfer M, Stengel A, Bock C, Cazzola M, Gisslinger H, Kralovics R. Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms. Blood. 2019 Jul 11;134(2):199-210.

Müller C, Wendt J, Rauscher S, Sunder-Plassmann R, Richtig E, Fae I, Fischer G, Okamoto I. Risk Factors of Subsequent Primary Melanomas in Austria. JAMA Dermatol. 2019 Feb 1;155(2):188-195.

Faé I, Wenda S, Grill C, Fischer GF HLA-B*44:138Q: Evidence for a confined deletion and recombination events in an otherwise unaffected HLA-haplotype. HLA. 2019 Feb;93(2-3):89-96

Villazala-Merino S, Rodriguez-Dominguez A, Stanek V, Campion NJ, Gattinger P, Hofer G, Froeschl R, Fae I, Lupinek C, Vrtala S, Breiteneder H, Keller W, Perkmann T, Nakamura R, Pickl WF, Valenta R, Eckl-Dorna J, Niederberger V. Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation. J Allergy Clin Immunol. 2020 Mar;145(3):958-967

Koblischke M, Spitzer FS, Florian DM, Aberle SW, Malafa S, Fae I, Cassaniti I, Jungbauer C, Knapp B, Laferl H, Fischer G, Baldanti F, Stiasny K, Heinz FX, Aberle JH. CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection. Front Immunol. 2020 Jan 23;11:16.

Doberer K, Bond G, Kläger J, Regele H, Strassl R, Reindl-Schwaighofer R, Scheriau G, Wahrmann M, Kikić Ž, Faé I, Fischer G, Böhmig GA, Eskandary F. Immunoadsorption Combined with Membrane Filtration to Counteract Early Treatment-Refractory Antibody-Mediated Rejection. Blood Purif. 2020 Mar 19:1-10

Ondrej Viklicky, Sebastian Krivanec , Hana Vavrinova , Gabriela Berlakovich, Tomas Marada, Janka Slatinska, Tereza Neradova, Renata Zamecnikova, Andreas Salat, Michael Hofmann, Gottfried Fischer, Antonij Slavcev, Pavel Chromy, Rainer Oberbauer, Tomas Pantoflicek , Sabine Wenda, Elisabeth Lehner, Ingrid Fae, Paolo Ferrari, Jiri Fronek , Georg A Böhmig  Crossing borders to facilitate live donor kidney transplantation: the Czech-Austrian kidney paired donation program - a retrospective study Transpl Int 2020 Oct;33(10):1199-1210.  

Benedikt Agerer, Maximilian Koblischke, Venugopal Gudipati, Luis Fernando Montaño-Gutierrez,  Mark Smyth,  Alexandra Popa, Jakob-Wendelin Genger, Lukas Endler, David M Florian, Vanessa Mühlgrabner, Marianne Graninger, Stephan W Aberle, Anna-Maria Husa, Lisa Ellen Shaw, Alexander Lercher, Pia Gattinger, Ricard Torralba-Gombau, Doris Trapin, Thomas Penz, Daniele Barreca, Ingrid Fae, Sabine Wenda, Marianna Traugott, Gernot Walder, Winfried F Pickl , Volker Thiel , Franz Allerberger, Hannes Stockinger, Elisabeth Puchhammer-Stöckl, Wolfgang Weninger, Gottfried Fischer, Wolfgang Hoepler, Erich Pawelka, Alexander Zoufaly, Rudolf Valenta, Christoph Bock, Wolfgang Paster, René Geyeregger, Matthias Farlik, Florian Halbritter, Johannes B Huppa, Judith H Aberle, Andreas Bergthaler; SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses, Sci Immunol 2021 Mar 4;6(57):eabg6461

Bernhard Kratzer, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Friedrich Tuppy, Melanie Feichter, Pia Gattinger, Kristina Borochova, Yulia Dorofeeva, Inna Tulaeva, Milena Weber, Katharina Grabmeier-Pfistershammer, Peter A Tauber, Marika Gerdov, Bernhard Mühl, Thomas Perkmann, Ingrid Fae, Sabine Wenda, Harald Führer, Rainer Henning, Rudolf Valenta, Winfried F Pickl; Immunological imprint of COVID-19 on human peripheral blood leukocyte populations Allergy 2021 Mar;76(3):751-765.

Anita Borski, Alexander Kainz, Nicolas Kozakowski, Heinz Regele, Johannes Kläger, Robert Strassl, Gottfried Fischer, Ingrid Faé, Sabine Wenda, Željko Kikić, Gregor Bond, Roman Reindl-Schwaighofer, Katharina A Mayer, Michael Eder, Markus Wahrmann, Susanne Haindl, Konstantin Doberer, Georg A Böhmig, Farsad Eskandary Early Estimated Glomerular Filtration Rate Trajectories After Kidney Transplant Biopsy as a Surrogate Endpoint for Graft Survival in Late Antibody-Mediated Rejection; Front Med (Lausanne). 2022 Apr 21;9:817127

Accordion Liste Text

Berufserfahrung

• Seit 1984 Universitätsklinik für Blutgruppenserologie und Transfusionsmedizin
• Erythrozytenlabor
• HLA Antikörperlabor
• Zellkultur für MLC Testung und Etablierung von EBV Zelllinien
• Ab 1987 maßgebliche Mitarbeit am Aufbau des HLA-DNA Typisierungslabors
• Erfahrung in SSP, SSO, SBT NGS, qPCR Techniken

Berufsausbildung

• 2016 ESHI (European Specialisation in Histocompatibility and Immunogenetics) Honorary Diploma
• 2008-2010 Masterlehrgang Biomedizinische Analytik, FH Campus Wien, Wien, Österreich
• Masterarbeit: Bestimmung von ILT Polymorphismen, Bestimmung des ILT5-ILT8 Polymorphismus in Familienstudien
• 1980-1983 Schule für den medizin-technischen Laboratoriumsdienst der Stadt Wien, Wien, Österreich

Mitgliedschaften

• Seit 1988 DGI-Mitglied
• Seit 1995 EFI-Mitglied
• 2012-2020 Mitglied European Federation for Immunogenetics (EFI) Standard Committee
• Bis 2012  Mitglied – Fachkompetenz Immungenetik der dt. Gesellschaft für Immungenetik
• (DGI)
• 2012-2014 Beisitzer im Board der DGI
• 2008-2012 Mitglied im Fortbildungskomitee der DGI
• Ab 1998 EFI Inspektor für Labore in und außerhalb Europas
• Ab 2013 EFI Commisioner für Labore in Region 5 (Österreich, Tschechien, Polen, Russland, Slowenien, Kasachstan)

Tätigkeiten

• Technical Supervisor für HLA Antikörperlabor und HLA-DNA Labor
  • Stellv. QM an der Blutgruppenserologie
• Etablierung HLA Next Generation Sequenzierung
• Etablierung Sequenzierung nicht-klassischer HLA Gene
• Etablierung non-HLA Antikörpertestung
• Etablierung dd-cf DNA im post-transplant Monitoring
• Seit 1998 CET-EPT Ringversuchsprovider für HLA Labore in Österreich, Tschechien, Polen, Ungarn, Slowenien, Kroatien, Serbien, Bulgarien, Rumänien, Armenien, Russland, Kasachstan, Slowakei

Betreuung von Bachelorarbeiten an der FH Campus Wien

• 2008 Mohammed Helal Uddin: A DNA based comparison of the distribution of the                 HLA Class I alleles in HIV+ patients and HIV- controls, to test whether specific HLA alleles are associated with alterations in the risk off HIV seropositivity
• 2011 Anton Klotz: Etablierung allelspezifischer Primer für HLA-C
• 2012 Nina Benitschka: C4d-FACS- Crossmatch
• 2012 Elisabeth Krieger: Etablierung von sequenzspeifischen Primern für HLA-B
• 2013 Vanessa Mayr: Die Verteilung bekannter und neuer HLA-G Allele in einer österreichischen Population
• 2014 Anita Thu Huong Nguyen: HLA-G Whole Gene Sequencing mittels Next Generation Sequencing am Ion Torrent Personal Genom Machine
• 2016 Cherilyn Cikan: GAMMA-Type Testing: A Retrospective Cohort-Study of AML Patients
• 2009-2021 Vorlesung über Sequenziertechniken für Masterlehrgang Biomedizinische Analytik, FH Campus Wien, Wien, Österreich

Preise

• 1995 MTA Preis der DGI für besondere Leistungen im Bereich HLA

1. Beate M. Rüger, Tanja Buchacher, Eva-Maria Dauber, Markus Pasztorek, Pavel Uhrin, Michael B. Fischer, Johannes M. Breuss, Gerda C. Leitner (2020). De novo vessel formation through cross-talk of blood-derived cells and mesenchymal stromal cells in the absence of pre-existing vascular structures. Front Bioeng Biotechnol 8:602210. DOI: 10.3389/fbioe.2020.602210
2. Nina Kastner, Julia Mester-Tonczar, Johannes Winkler, Denise Traxler, Andreas Spannbauer, Beate M. Rüger, Georg Goliasch, Noemi Pavo, Mariann Gyöngyösi, Katrin Zlabinger (2020). Comparative effect of MSC secretome to MSC co-culture on cardiomyocyte gene expression under hypoxic conditions in vitro. Front Bioeng Biotechnol 8:502213. DOI: 10.3389/fbioe.2020.502213
3. Rüger BM, Buchacher T, Giurea A, Kubista B, Fischer MB, Breuss JM (2018). Vascular Morphogenesis in the Context of Inflammation: Self-Organization in a Fibrin-Based 3D Culture System. Front Physiol 9: 679. DOI: 10.3389/fphys.2018.00679
4. Haider T, Höftberger R, Rüger B, Mildner M, Blumer R, Mitterbauer A, Buchacher T, Sherif C, Altmann P, Redl H, Gabriel C, Gyöngyösi M, Fischer MB, Lubec G, Ankersmit HJ (2015). The secretome of apoptotic human peripheral blood mononuclear cells attenuates secondary damage following spinal cord injury in rats. Exp Neurol 267: 230-242. DOI: 10.1016/j.expneurol.2015.03.013
5. Buchacher T, Wiesinger-Mayr H, Vierlinger K, Rüger BM, Stanek G, Fischer MB, Weber V (2014). Human blood monocytes support persistence, but not replication of the intracellular pathogen C. pneumoniae. BMC Immunol 15(1):60. DOI: 10.1186/s12865-014-0060-1
6. Walzer SM, Cetin E, Grübl-Barabas R, Sulzbacher I, Rueger B, Girsch W, Toegel S, Windhager R, Fischer MB (2014). Vascularization of primary and secondary ossification centres in the human growth plate. BMC Dev Biol 14: 36. DOI: 10.1186/s12861-014-0036-7
7. David Hollemann, Genya Yanagida, Beate M Rüger, Csilla Neuchrist, Michael B Fischer (2011). New vessel formation in peritumoral area of squamous cell carcinoma of the head and neck. Head & Neck 34(6):813-20. DOI: 10.1002/hed.21814
8. Beate M. Rüger, Johannes Breuss, David Hollemann, Genya Yanagida, Michael B. Fischer, Isabella Mosberger, Irene Lang, Andreas Chott, Paul Davis, Paul Höcker, Markus Dettke (2008). Vascular morphogenesis by adult bone-marrow (BM) progenitor cells in three dimensional (3D) fibrin matrices. Differentiation 76:772-783. https://doi.org/10.1111/j.1432-0436.2007.00259.x
9. Vaculik C, Rüger BM, Yanagida G, Hollemann D, Soleiman A, Losert UM, Chen J, Fischer MB (2008). Shift of C3 deposition from localization in the glomerulus into the tubulo-interstitial compartment in the absence of secreted IgM in immune complex glomerulonephritis. Clin Exp Immunol 151(1):146-154. DOI: 10.1111/j.1365-2249.2007.03534.x
10. Fischer MB, Rüger B, Vaculik C, Becherer A, Wadsak W, Yanagida G, Losert UM, Chen J, Carroll MC, Eibl MM (2007). The presence of MOMA-2+ macrophages in the outer B cell zone and protection of the splenic micro-architecture from LPS-induced destruction depend on secreted IgM. Eur J Immunol 37(10):2825-2833.  DOI: 10.1002/eji.200636996
11. Giurea A, Rüger B, Hollemann D, Yanagida G, Kotz R, Fischer MB (2006). STRO-1+ mesenchymal precursor cells located in synovial surface projections of patients with osteoarthritis. Osteoarthritis Cartilage 14(9):938-43. https://doi.org/10.1016/j.joca.2006.02.014
12. Polgar D, Leisser C, Maier S, Strasser S, Rüger B, Dettke M, Khorchide M, Simonitsch I, Cerni C, Krupitza G (2005). Truncated ALK derived from chromosomal translocation t(2;5)(p23;q35) binds to the SH3 domain of p85-PI3K. Mutation Res 570: 9-15. DOI: 10.1016/j.mrfmmm.2004.09.011 
13. Rüger BM, Giurea A, Wanivenhaus AH, Zehetgruber H, Hollemann D, Yanagida G, Groger M, Petzelbauer P, Smolen JS, Hoecker P Fischer MB (2004). Endothelial Precursor Cells in the Synovial Tissue of Patients with Rheumatoid Arthritis and Osteoarthritis. Arthritis Rheumatism 50(7): 2157-2166. DOI: 10.1002/art.20506
14. Dettke M, Jurko S, Rüger BM, Leitner G, Greinix HT, Kalhs P, Fischer MB, Hocker P (2001). Increased serum flt3-ligand in healthy donors undergoing granulocyte colony-stimulating factor-induced peripheral stem cell mobilization. J Hematother Stem Cell Res 10(2): 317-320. DOI: 10.1089/15258160151135105
15. Walker R, Dixon S, Rüger B, Davis P, Hildebrant F, Kremer M, Eccles M, McNoe L, Watson M, Reid J (2001). Familial fibronectin glomerulopathy: analysis of chromosome 1q32 and uteroglobin gene loci in a large New Zealand family. Nephrology 6: 191-197. https://doi.org/10.1046/j.1440-1797.2001.00062.x
16. Rüger BM, Erb KJ, He Y, Lane JM, Davis PF, Hasan Q (2000). Interleukin-4 transgenic mice develop glomerulosclerosis independent of immunoglobulin deposition. Eur J Immunol 30(9): 2698-2703. DOI: 10.1002/1521-4141(200009)30:9<2698
17. Hasan Q, Rüger BM, Tan ST, Gush J, Davis PF (2000). Clusterin/apoJ expression during the development of hemangioma. Hum Pathol 31(6): 691-697. DOI: 10.1053/hupa.2000.7638
18. Tan ST, Velickovic M, Rüger BM, Davis PF (2000). Cellular and extracellular markers of hemangioma. Plast Reconstr Surg 106(3): 529-538. DOI: 10.1097/00006534-200009030-00001
19. Delahunt B, Stehbens WE, Gilbert-Barness E, Shozawa T, Rüger BM (2000). Progeria kidney has abnormal mesangial collagen distribution. Pediatr Nephrol 15(3-4): 279-285. DOI: 10.1007/s004670000479
20. Tan ST, Hasan Q, Velickovic M, Rüger BM, Davis RP, Davis PF (2000). A novel In Vitro human Model of Hemangioma. Modern Pathol 13(1):92-99. DOI: 10.1038/modpathol.3880014
21. Greenhill NS, Rüger BM, Hasan Q, Davis PF (2000). The α1(VIII) and α2(VIII) Collagen Chains Form Two Distinct Homotrimeric Proteins in vivo. Matrix Biol 19(1): 19-28. DOI: 10.1016/s0945-053x(99)00053-0
22. Kitching AR, Rüger BM, Davis PF (2000). Oxidant stress is increased within the glomerulus in experimental diabetic nephropathy. Nephrology 5(4): 263-270. https://doi.org/10.1046/j.1440-1797.2000.00011.x
23. Rüger BM, Hasan Q, Erb KJ, Davis PF (1999). Progression of Renal Disease in Interleukin-4 Transgenic Mice: Involvement of Transforming Growth Factor- beta. Int J Exp Pathol 80(3): 113-123. DOI: 10.1046/j.1365-2613.1999.00105.x
24. Erb KJ, Rüger B, von Breveren M, Ryffel B, Schimpl A, Rivett K (1997). Constitutive Expression of Interleukin (IL)-4 In Vivo Causes Autoimmune-type Disorders in Mice. J Exp Med 185(2): 329-339. DOI: 10.1084/jem.185.2.329
25. Davis PF, He Y, Furneaux RH, Johnston PS, Rüger BM, Slim GC (1997). Inhibition of Angiogenesis by Oral Ingestion of Powdered Shark Cartilage in a Rat Model. Microvascular Res 54: 178-182. DOI: 10.1006/mvre.1997.2036
26. Rüger B, Hasan Q, Greenhill NS, Davis PF, Dunbar PR, Neale TJ (1996). Mast Cells and Type VIII Collagen in Human Diabetic Nephropathy. Diabetologia 39: 1215-1222. DOI: 10.1007/BF02658509
27. Neale TJ, Rüger B, Macaulay H, Dunbar PR, Hasan Q, Bourke A, Murray-McIntosh RP, Kitching RA (1995). Tumour necrosis factor-alpha is expressed by glomerular visceral epithelial cells in human membranous nephropathy. Am J Pathol 146: 1444-1454. PMID: 7778683
28. Rüger BM, Sawada H, Dunbar PR, Hasan Q, Kittelberger R, Greenhill NS, Neale TJ (1994). Human mast cells produce type VIII collagen in vivo. Int J Exp Pathol 75: 397-404. PMID: 7734329
29. Neale TJ, Ojha PP, Exner M, Poczewski H, Davis PF, Rüger B, Witztum J, Kerjaschki D (1994). Proteinuria in Passive Heymann Nephritis is associated with lipid peroxidation and formation of adducts on type IV collagen. J Clin Invest 94: 1577-1584. DOI: 10.1172/JCI117499

Professional Experience, Appointments, Research

• October 1999–present:
  • Department of Blood Group Serology and Transfusion Medicine, Integrative Cell Biology Research Laboratory, Medical University Vienna
  • Research focus: Establishment of reparative 3D niche models
• April 1992–April 1999:
  • Department of Medicine, University of Otago, Wellington, New Zealand, Immunopathology Research Laboratory
  • Renal research, mast cell-, extracellular matrix- and angiogenesis research
• July 1984–March 1992:
  • Institute of Clinical Pathology, University of Vienna, Haematopathology Laboratory
  • Diagnostic immunohistochemistry of haematological disorders
• April 1984–June 1984:
  • Ludwig Boltzmann Institute of Experimental Anaesthesia and Intensive Care, University of Vienna
  • Endorphin research
• Jan 1982–March 1984
  • 2^nd Medical University Clinic, University of Vienna
  • Prostaglandin research project

Education

• 2014–2021
  • PhD programme Vascular Biology
  • Department of Blood Group Serology and Transfusion Medicine, Medical University of Vienna, Austria
  • Thesis: Neovascularization in the context of inflammation: Three-dimensional in vitro culture models to study postnatal vascular morphogenesis; Supervisor: Ao.Prof. Dr. Johannes M. Breuss
• 1996–1998
  • Master of Medical Laboratory Science (MMLSc),
  • University of Otago, Wellington, New Zealand
  • Thesis: The roles of interleukin-4 and transforming growth factor-beta in the development of progressive renal disease
  • Supervisors: Dr. Paul F. Davis, Prof. Dr. Linda Holloway
• 1979–1981
  • School of Biomedical Laboratory Science, Vienna, Austria

International Collaborations

• Jan/Feb 1997
  • Co-operative project under the NZ/FRG Scientific and Technological Cooperation (STC) Agreement Programme,
  • Institute of Biochemistry, Cologne (Prof. Dr. Mats Paulsson)
  • Preparation of beta-2 laminin fusion proteins for the production of chain-specific antibodies

Awards

• Best Poster Award, Bristol Meyer Squibb, March 1994:
  • Australian and New Zealand Society of Nephrology (ANZSN) Scientific Meeting, Adelaide
  • Rüger BM, Dunbar PR, Hasan Q, Greenhill NS, Sawada H, Neale TJ: Mast Cells and Type VIII Collagen in Human Diabetic Nephropathy
• Young Investigator Award, September 1996:
  • International Society of Nephrology (ISN) Forefronts in Nephrology: Cytokines and Adhesion Molecules in Tissue Injury and Repair, Snowbird, Utah
  • Rüger BM, Hasan Q, Davis PF, Pidgeon GB, Greenhill NS, Erb KJ: Interleukin-4 transgenic (IL-4 tg) mice: a new model of progressive glomerulosclerosis
• Best Abstract Award, September 2008:
  • Deutsche Gesellschaft für Transfusionsmedizin und Immunhämatologie (DGTI), Düsseldorf, Germany:
  • Beate M. Rüger, David Hollemann, Genya Yanagida, Michael B. Fischer, Markus Dettke (2008). Vascular morphogenesis by adult bone-marrow (BM) progenitor cells in three dimensional (3D) fibrin matrices

• Bayat B, Lowack J, Audrain M, Croisille L, Curtis B, Dangerfield R, Esmaeili B, Grabowski C, Keller M, Kim H, Kroll H, Kvanka MM, Kwok J, Moritz E, Nathalang O, Nelson D, Nielsen KR, Pahn G, Poles A, Poreclijn L, Sachs UJ, Schönbacher M, Körmöczi GF, Kupatawintu P, Takahashi D, Uhrynowska M, Flesch B, Fung YL: World human neutrophil antigens investigation survey. Vox sanguinis 2023
• Schönbacher M, Banfi C, Berghold A, Matzhold EM, Wagner T, Mayr WR, Körmöczi GF: Immunoglobulin Class Profiles of ABO antibodies in Saliva and Serum of Healthy Individuals. Transfusion Medicine & Hemotherapy 2023; 50; 294-302
• Matzhold EM, Körmöczi GF, Banfi C, Schönbacher M, Drexler-Helmberg C, Steinmetz I, et al.: Lower Levels of ABO Anti-A and Anti-B of IgM, IgG and IgA Isotypes in the Serum but not the Saliva of COVID-19 Convalescents. Journal of Clinical Medicine 2022; 11: 4513.
• Schönbacher M, Körmöczi UM, Laccone F, Pickl W, Pelzl B, Körmöczi GF. Neonatal alloimmune neutropenia caused by maternal anti-FcγRIIIB antibodies. Transfusion Medicine and Hemotherapy. 2021;48(suppl 1):40 (Poster-Abstract)
• Torreiter PP, Macher S, Matzhold EM, Resch B, Klaritsch P, Körmöczi GF, Polin H, Neuhold L, Schönbacher M, Schlenke P, Wagner T: Ethical issues and management of fetal hemolytic anemia caused by anti-Rh17 in a multipara with rare –D– phenotype. Transfusion Medicine and Hemotherapy. 2021, 48(3): 183-187
• Schönbacher M, Aichinger N, Weidner L, Jungbauer C, Grabmer C, Schuha B, Rohde E, Mayr WR, Körmöczi GF: Leukocyte-Reactive Antibodies in Female Blood Donors: The Austrian Experience. Transfusion Medicine and Hemotherapy. 2020. 48(2): 99-108
• Flesch BK, Reil A, Nogués N, Canals C, Bugert P, Schulze TJ, Huiskes E, Porcelijn L, Höglund P, Ratcliffe P, Schönbacher M, Kerchrom H, Kellershohn J, Bayat B: Multicenter Study on Differential Human Neutrophil Antigen 2 Expression and Underlying Molecular Mechanisms. Transfusion Medicine and Hemotherapy. 2020. 47(5): 385-395.
• Matzhold EM, Wagner T, Drexler C, Schönbacher M, Körmöczi GF: Aberrant ABO B Phenotype with Irregular Anti-B Caused by a Para-Bombay FUT1 Mutation. Transfusion Medicine and Hemotherapy. 2020;47(1): 94-97.
• Dauber EM, Mayr WR, Hustinx H, Schönbacher M, Budde H, Legler TJ, König M, Haas OA, Fritsch G, Körmöczi GF: Somatic mosaicisms of chromosome 1 at two different stages of ontogenetic development detected by Rh blood group discrepancies. Haematologica 2019;104(3): 632-638.
• Matzhold EM, Polin H, Körmöczi GF, Macher S, Schönbacher M, Wagner T: RHD del28Phe (DMW) encoded by a novel in-frame deletion resulting in reduced D antigen expression. Transfusion. 2019; 59(9): 3033-3034.
• Schönbacher M, Mayr WR, Schulze TJ, Leitner G, Schmidt C, Hofbauer G, Tolios A, Körmöczi GF: Time from venipuncture to cell isolation: Impact on granulocyte-reactive antibody testing. Clinical biochemistry. 2019;63: 72-78.
• Heinzl MW, Schönbacher M, Dauber EM, et al.: Detection of granulocyte-reactive antibodies: a comparison of different methods. Vox Sang 2015, 108: 287-293
• Schönbacher M, Heinzl MW, Dauber EM, et al.: Granulocyte-reactive antibodies are associated with red blood cell alloimmunization. Vox Sang 2014, 107: 200-203

Positionen und Funktionen

Seit 11/2011:

• Aufbau & technische Leitung des Granulozytenlabors
• Experimentelle Erythrozyten- und Granulozytenserologie
• Bearbeitung immunhämatologischer Spezialfälle

2008–2011: Zentrallabor im Krankenhaus der barmherzigen Brüder Wien

2006–2008: Research Associate bei Baxter Bioscience Wien

Berufsausbildung

• 2015-2022: Doctoral Programme for Applied Medical Sciences an der Medizinischen Universität Wien
• 2010–2012: Masterlehrgang Biomedizinische Analytik an der FH Campus Wien
• 2003–2006: Akademie für den med. techn. Laboratoriumsdienst des Landes Steiermark

Tätigkeiten (Forschung & Routine)

• 3/2022 Einreichung der Dissertation „Leukocyte-reactive antibodies in Austria female blood donors“ betreut von Ao. Univ.-Prof. Dr. Günther Körmöczi, MME
• Seit 04/2021 Durchflußzytometrische Bestimmung von ABO Antikörpern in Serum und Speichel
• 2017–2020 Screening von Blutspenderinnen auf granulozytenreaktive Antikörper
• Seit 2015 Charakterisierung wärmereaktiver antierythrozytärer Autoantikörper
• Seit 2013 Evaluierung neuer Methoden für den Einsatz in der Granulozytenimmunologie
• Seit 2012 Erforschung immunhämatologischer Spezialfälle hinsichtlich erythrozytärer (z.B. ABO, Rh D) bzw. granulozytärer (HNA) Merkmale
• 2011–2013 Etablierung granulozytenimmunologischer Methoden und Aufbau des Granulozytenlabors
• 2006–2008 Molekulare Wirkmechanismen des Makrophagen-Migrations-Inhibitions-Faktors (MIF) in der Sepsis

Preise

• 2015 Preis für Biomedizinische Analytikerinnen „für Verdienste im Bereich der Transfusionsmedizin“ von der österreichischen Gesellschaft für Blutgruppenserologie und Transfusionsmedizin (ÖGBT)
• 2013 Best Abstract Preis für „Prävalenz granulozytenreaktiver Antikörper bei alloexponierten Frauen“ von der österreichischen Gesellschaft für Blutgruppenserologie und Transfusionsmedizin (ÖGBT)

Early Estimated Glomerular Filtration Rate Trajectories After Kidney Transplant Biopsy as a Surrogate Endpoint for Graft Survival in Late Antibody-Mediated Rejection. Borski A, Kainz A, Kozakowski N, Regele H, Kläger J, Strassl R, Fischer G, Faé I, Wenda S, Kikić Ž, Bond G, Reindl-Schwaighofer R, Mayer KA, Eder M, Wahrmann M, Haindl S, Doberer K, Böhmig GA, Eskandary F. Front Med (Lausanne). 2022 Apr 21;9:817127. doi: 10.3389/fmed.2022.817127. eCollection 2022. PMID: 35530045

Effects of Reduced-Dose Anti-Human T-Lymphocyte Globulin on Overall and Donor-Specific T-Cell Repertoire Reconstitution in Sensitized Kidney Transplant Recipients. Aschauer C, Jelencsics K, Hu K, Gregorich M, Reindl-Schwaighofer R, Wenda S, Wekerle T, Heinzel A, Oberbauer R. Front Immunol. 2022 Feb 25;13:843452. doi: 10.3389/fimmu.2022.843452. eCollection 2022. PMID: 35281040

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses. Agerer B, Koblischke M, Gudipati V, Montaño-Gutierrez LF, Smyth M, Popa A, Genger JW, Endler L, Florian DM, Mühlgrabner V, Graninger M, Aberle SW, Husa AM, Shaw LE, Lercher A, Gattinger P, Torralba-Gombau R, Trapin D, Penz T, Barreca D, Fae I, Wenda S, Traugott M, Walder G, Pickl WF, Thiel V, Allerberger F, Stockinger H, Puchhammer-Stöckl E, Weninger W, Fischer G, Hoepler W, Pawelka E, Zoufaly A, Valenta R, Bock C, Paster W, Geyeregger R, Farlik M, Halbritter F, Huppa JB, Aberle JH, Bergthaler A. Sci Immunol. 2021 Mar 4;6(57):eabg6461. doi: 10.1126/sciimmunol.abg6461. PMID: 33664060

Concordance with established tests and reproducibility of results obtained with a new single antigen chip array for HLA antibody detection (HISTO SPOT® HLA AB). Launhardt K, Lefevre V, Souplet V, Prantl L, Marget M, Hovoricova B, Wenda S, Olivier C. J Immunol Methods. 2021 Apr;491:112971. doi: 10.1016/j.jim.2021.112971. Epub 2021 Feb 4. PMID: 33549571

Immunological imprint of COVID-19 on human peripheral blood leukocyte populations Kratzer B, Trapin D, Ettel P, Körmöczi U, Rottal A, Tuppy F, Feichter M, Gattinger P, Borochova K, Dorofeeva Y, Tulaeva I, Weber M, Grabmeier-Pfistershammer K, Tauber PA, Gerdov M, Mühl B, Perkmann T, Fae I, Wenda S, Führer H, Henning R, Valenta R, Pickl WF. Allergy. 2021 Mar;76(3):751-765. doi: 10.1111/all.14647. Epub 2020 Nov 22.

Donor-specific HLA antibodies after fresh decellularized vs cryopreserved native allograft implantation. Coti I, Wenda S, Andreeva A, Kocher A, Laufer G, Fischer G, Andreas M. HLA. 2020 Nov;96(5):580-588. doi: 10.1111/tan.14077. Epub 2020 Oct 13. PMID: 32975376 Free PMC article.

Crossing borders to facilitate live donor kidney transplantation: the Czech-Austrian kidney paired donation program - a retrospective study. Viklicky O, Krivanec S, Vavrinova H, Berlakovich G, Marada T, Slatinska J, Neradova T, Zamecnikova R, Salat A, Hofmann M, Fischer G, Slavcev A, Chromy P, Oberbauer R, Pantoflicek T, Wenda S, Lehner E, Fae I, Ferrari P, Fronek J, Böhmig GA. Transpl Int. 2020 Oct;33(10):1199-1210. doi: 10.1111/tri.13668. Epub 2020 Jun 23. PMID: 32491249

Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Workshop. Osoegawa K, Vayntrub TA, Wenda S, De Santis D, Barsakis K, Ivanova M, Hsu S, Barone J, Holdsworth R, Diviney M, Askar M, Willis A, Railton D, Laflin S, Gendzekhadze K, Oki A, Sacchi N, Mazzocco M, Andreani M, Ameen R, Stavropoulos-Giokas C, Dinou A, Torres M, Dos Santos Francisco R, Serra-Pages C, Goodridge D, Balladares S, Bettinotti MP, Iglehart B, Kashi Z, Martin R, Saw CL, Ragoussis J, Downing J, Navarrete C, Chong W, Saito K, Petrek M, Tokic S, Padros K, Beatriz Rodriguez M, Zakharova V, Shragina O, Marino SR, Brown NK, Shiina T, Suzuki S, Spierings E, Zhang Q, Yin Y, Morris GP, Hernandez A, Ruiz P, Khor SS, Tokunaga K, Geretz A, Thomas R, Yamamoto F, Mallempati KC, Gangavarapu S, Kanga U, Tyagi S, Marsh SGE, Bultitude WP, Liu X, Cao D, Penning M, Hurley CK, Cesbron A, Mueller C, Mytilineos J, Weimer ET, Bengtsson M, Fischer G, Hansen JA, Chang CJ, Mack SJ, Creary LE, Fernandez-Viña MA. Hum Immunol. 2019 Apr;80(4):228-236. doi: 10.1016/j.humimm.2019.01.009. Epub 2019 Feb 6. Review.

HLA-B*44:138Q: Evidence for a confined deletion and recombination events in an otherwise unaffected HLA-haplotype. Faé I, Wenda S, Grill C, Fischer GF. HLA. 2019 Feb;93(2-3):89-96. doi: 10.1111/tan.13439. Epub 2019 Jan 6.

An HLA-B7-specific antibody in an HLA-B*07 positive patient explained by a nonexpressed allele (HLA-B*07:181N). Wenda S, Faé I, Fischer GF. HLA. 2017 Jul;90(1):32-35. doi: 10.1111/tan.13045. Epub 2017 Apr 17

Standardized genotyping of HLA STR by CE as surrogate for HLA class I and II markers and for identification of HLA identical siblings. Dauber EM, Wenda S, Schwartz-Jungl EM, Glock B, Mayr WR. Electrophoresis. 2016 Mar;37(5-6):849-59

Sequence-based definition of eight short tandem repeat loci located within the HLA-region in an Austrian population. Dauber EM, Wenda S, Schwartz-Jungl EM, Glock B, Mayr WR. Forensic Sci Int Genet. 2015 Jan;14:168-73.

Resolution of HLA-B*44:02:01G, -DRB1*14:01:01G and -DQB1*03:01:01G reveals a high allelic variability among 12 European populations. Vidan-Jeras B, Buhler S, Dubois V, Grubic Z, Ivanova M, Jaatinen T, Ligeiro D, Lokki ML, Papasteriades C, Poli F, Spyropoulou-Vlachou M, Tordai A, Viken MK, Wenda S, Nunes JM, Sanchez-Mazas A, Tiercy JM. Tissue Antigens. 2014 Nov;84(5):459-64.

Administration of recombinant human granulocyte-colony-stimulating factor does not induce long-lasting detectable epigenetic alterations in healthy donors. Leitner GC, Faschingbauer M, Wenda S, Weigel G, Fischer G. Transfusion. 2014 Dec;54(12):3121-6.

HLA typing by next-generation sequencing - getting closer to reality. Gabriel C, Fürst D, Faé I, Wenda S, Zollikofer C, Mytilineos J, Fischer GF. Tissue Antigens. 2014 Feb;83(2):65-75.

The distribution of MICA alleles in an Austrian population: evidence for increasing polymorphism. Wenda S, Faé I, Sanchez-Mazas A, Nunes JM, Mayr WR, Fischer GF. Hum Immunol. 2013 Oct;74(10):1295-9

ACTBP2 (alias ACTBP8) is localized on chromosome 6 (band 6q14). Wenda S, Dauber EM, Schwartz DW, Jungbauer C, Weirich V, Wegener R, Mayr WR. Forensic Sci Int. 2005 Mar 10;148(2-3):207-9.

C2_4_4 microheterogeneity and HLA Class I. Wenda S, Dauber EM, Stadlbacher S, Glock B, Fischer M, Körmöczi GF, Mayr WR. Tissue Antigens. 2003 Jun;61(6):484-6.

The tetranucleotide repeat polymorphism C2_4_4: population data and linkage disequilibria with HLA class I. Stadlbacher S, Dauber EM, Wenda S, Glock B, Hafner M, Körmöczi GF, Mayr WR. Immunobiology. 2003;207(2):137-40.

Berufserfahrung und Ausbildung

• seit 1989 - Universitätsklinik für Blutgruppenserologie und Transfusionsmedizin
• seit 2006 - Molekulare Diagnostik DNA-Labor
• 1998-2001 & 1989-1994 - HLA-Antikörperlabor
• 2001-2006 - Labor für Hämogenetik
• 2010-2012 - Masterlehrgang Biomedizinische Analytik, FH Campus Wien, Wien, Österreich: Masterarbeit: Verteilung der MICA (Major Histocompatibility Complex Class I Chain-Related Gene A) Allele innerhalb einer österreichischen Bevölkerung und deren Kopplungsungleichgewicht zu HLA-B Allelen
• 2016 - ESHI (European Specialisation in Histocompatibility and Immunogenetics) Honorary Diploma

Mitgliedschaften

• seit 2021 - Mitglied European Federation for Immunogenetics (EFI) Standard Committee
• seit 2006 - DGI-Mitglied (dt. Gesellschaft für Immungenetik)
• seit 2006 - EFI-Mitglied (European Federation for Immunogenetics)
• bis 2012 - Mitglied Fachkompetenz Immungenetik der dt. Ges. für Immungenetik (DGI)

Tätigkeiten

• Technical Supervisor – HLA-Antikörper Labor und HLA-DNA Labor
• Kidney Paired Donation Programm (Österreich-Tschechien-Israel)
• Etablierung HLA Next Generation Sequenzierung
• Etablierung MICA/MICB Sequenzierung
• Etablierung non-HLA Antikörpertestung
• Etablierung dd-cf DNA im post-transplant Monitoring
• CET- EPT Ringversuchsprovider
• Stellv. Qualitätsmanagement
• 2019-2021 - Lehre Sequenziertechnik Masterlehrgang Biomedizinische Analytik, FH Campus Wien
• seit 2013 - Betreuung Bachelorarbeiten Biomedizinische Analytik