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Labor für Transplantationsimmunologie

HLA-Antikörperdiagnostik und DNA-Labor-Typisierung
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Labor für Transplantationsimmunologie, HLA-Antikörperdiagnostik und DNA-Labor

Universitätsklinik für Transfusionsmedizin und Zelltherapie

Medizinische Universität Wien
Universitätsklinik für Transfusionsmedizin und Zelltherapie
Labor für Transplantationsimmunologie, HLA-Antikörperdiagnostik und DNA-Labor
AKH Hauptgebäude 4i, Währinger Gürtel 18–20, 1090 Wien

Tel. (HLA-Antikörperdiagnostik): +43 (0)1 40400-53290
Fax (HLA-Antikörperdiagnostik): +43 (0)1 40400-53360

Tel. (DNA-Labor-Typisierung): +43 (0)1 40400-53320
Fax (DNA-Labor-Typisierung): +43 (0)1 40400-73405

Ao.Univ.-Prof. Dr. med. univ. Gottfried Fischer

Leitung HLA Labor, Qualitätsmanager

Medizinische Universität Wien
Universitätsklinik für Transfusionsmedizin und Zelltherapie
Währinger Gürtel 18–20, 1090 Wien

Telefon: +43 (0)1 40400-53170
Pager (nur intern verfügbar): 81-6190
E-Mail: gottfried.fischer@meduniwien.ac.at

  • Immungenetik
  • Transplantationsimmunolgie
  • HLA
  • KIR

Positions, Functions and Skills

  • Since 1999 Quality Manager of the Department of Blood Group Serology and Transfusion Medicine
  • Certified quality manager and auditor (ISO 9001)
  • Since 03/1988 Head of the HLA/transplant immunology laboratory: HLA typing by serology, SSO, SSO, sequencing based typing
  • Since 09/1987 Blood group typing, screening and crossmatches for red cell concentrates, identification of red cell specific antibodies

Education, Training

  • 07/1999 Quality manager and auditor
  • 08/1994 Board examination: Blood group serology and transfusion medicine
  • 03/1993 Habilitation in blood group serology
  • 1985 Graduation from Medical School: MD (Dr. univ. med.)
  • 1978–1985 Medical School, University of Vienna

Research and scientific interests

  • Since 1987 Scientific work at the Department of Blood Group Serology
  • Initial focus molecular typing of the AB0 blood group system
  • Currently: immunogenetics, particularly HLA and KIR systems
  • 10/1991–09/1993 Sabbatical leave, visiting researcher at the Laboratory of Molecular Biology, Medical Research Council, Cambridge, UK; supervisor Dr. Cesar Milstein. Studies on somatic hypermutation of immunoglobulin genes (cloning and sequencing of immunoglobulin genes in mice)
  • 03/1985–02/1987 Research grant of the Ministry of Sciences at the institute of Immunology, supervisor Prof. Walter Knapp: Cell biology of lymphocytes and granulocytes (tissue culture, flow cytometry, monocloncal antibodies)

Scientific societies, memberships

  • Österreichische Gesellschaft für Allergologie und Immunologie (ÖGAI, member since 1985)
  • Deutsche Gesellschaft für Immunologie (DGfI, member since 1986)
  • Österreichische Gesellschaft für Hämatologie und Onkologie (ÖGHO, member since 1986)
  • Deutsche Gesellschaft für Immungenetik, (DGI, member since 1992)
  • Executive Board 1997–2001,
  • President 2004–2006, 2008–2010
  • European Federation of Immunogenetics (EFI, member since 1992)
  • Councillor 1997–1999
  • Member of the Committee for External Proficiency Testing 1999–2001
  • Chairman of the Education Committee 2001–2003
  • General Secretary of the Accreditation Committee 2006–2008
  • Chairman of the Accreditation Committee 2008–2011
  • President 2012–2015
  • Councillor of the International Histocompatibility and Workshop Group since 2012

Publikationen

1) Osoegawa K., et al. A new strategy for systematically classifying HLA alleles into serological specificities. HLA 2022 https://doi.org/10.1111/tan.14662

2) Borski A. et al. Early Estimated Glomerular Filtration Rate Trajectories After Kidney Transplant Biopsy as a Surrogate Endpoint for Graft Survival in Late Antibody-Mediated Rejection. Front Med (Lausanne) 2022; 9: 817127

3) Agerer B et al. SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses Sci Immunol. 2021 6(57): eabg6461

4) Stary, V., et al. A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses. Sci Immunol 5(2020).

5) Osorio-Jaramillo, E., et al. Molecular-level HLA mismatch is associated with rejection and worsened graft survival in heart transplant recipients - a retrospective study. Transpl Int 33, 1078-1088 (2020).

6) Lang, C., et al. Lung transplantation for COVID-19-associated acute respiratory distress syndrome in a PCR-positive patient. Lancet Respir Med 8, 1057-1060 (2020).

7) Creary, L.E., et al. Next-generation HLA typing of 382 International Histocompatibility Working Group reference B-lymphoblastoid cell lines: Report from the 17th International HLA and Immunogenetics Workshop. Hum Immunol 80, 449-460 (2019).

8) Coti, I., et al. Donor-specific HLA antibodies after fresh decellularized vs cryopreserved native allograft implantation. HLA 96, 580-588 (2020).

9) Aigner C, Böhmig GA, Eskandary F, Herkner H, Prohászka Z, Csuka D, Kain R, Gaggl M, Sunder-Plassmann R, Müller-Sacherer T, Oszwald A, Fischer G, Schmidt A, Sunder-Plassmann G. Preemptive plasma therapy prevents atypical hemolytic uremic syndrome relapse in kidney transplant recipients. Eur J Intern Med. 2020 Mar;73:51-58.

10) Koblischke M, Spitzer FS, Florian DM, Aberle SW, Malafa S, Fae I, Cassaniti I, Jungbauer C, Knapp B, Laferl H, Fischer G, Baldanti F, Stiasny K, Heinz FX, Aberle JH. CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection. Front Immunol. 2020 Jan 23;11:16.

11) Doberer K, Bond G, Kläger J, Regele H, Strassl R, Reindl-Schwaighofer R, Scheriau G, Wahrmann M, Kikić Ž, Faé I, Fischer G, Böhmig GA, Eskandary F. Immunoadsorption Combined with Membrane Filtration to Counteract Early Treatment-Refractory Antibody-Mediated Rejection. Blood Purif. 2020 Mar 19:1-10

12) Askar M, Madbouly A, Zhrebker L, Willis A, Kennedy S, Padros K, Rodriguez MB, Bach C, Spriewald B, Ameen R, Shemmari SA, Tarassi K, Tsirogianni A, Hamdy N, Mossallam G, Hönger G, Spinnler R, Fischer G, Fae I, Charlton R, Dunk A, Vayntrub TA, Halagan M, Osoegawa K, Fernández-Viña M. HLA Haplotypes In 250 Families: The Baylor Laboratory Results And A Perspective On A Core NGS Testing Model For The 17th International HLA And Immunogenetics Workshop. Hum Immunol. 2019 Nov;80(11):897-905.

13) Schischlik F, Jäger R, Rosebrock F, Hug E, Schuster M, Holly R, Fuchs E, Milosevic Feenstra JD, Bogner E, Gisslinger B, Schalling M, Rumi E, Pietra D, Fischer G, Faé I, Vulliard L, Menche J, Haferlach T, Meggendorfer M, Stengel A, Bock C, Cazzola M, Gisslinger H, Kralovics R. Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms. Blood. 2019 Jul 11;134(2):199-210

14) Reindl-Schwaighofer R, Heinzel A, Kainz A, van Setten J, Jelencsics K, Hu K, Loza BL, Kammer M, Heinze G, Hruba P, Koňaříková A, Viklicky O, Boehmig GA, Eskandary F, Fischer G, Claas F, Tan JC, Albert TJ, Patel J, Keating B, Oberbauer R; iGeneTRAiN consortium. Contribution of non-HLA incompatibility between donor and recipient to kidney allograft survival: genome-wide analysis in a prospective cohort. Lancet. 2019 Mar 2;393(10174):910-917.

15) Osoegawa K, Vayntrub TA, Wenda S, De Santis D, Barsakis K, Ivanova M, Hsu S, Barone J, Holdsworth R, Diviney M, Askar M, Willis A, Railton D, Laflin S, Gendzekhadze K, Oki A, Sacchi N, Mazzocco M, Andreani M, Ameen R, Stavropoulos-Giokas C, Dinou A, Torres M, Dos Santos Francisco R, Serra-Pages C, Goodridge D, Balladares S, Bettinotti MP, Iglehart B, Kashi Z, Martin R, Saw CL, Ragoussis J, Downing J, Navarrete C, Chong W, Saito K, Petrek M, Tokic S, Padros K, Beatriz Rodriguez M, Zakharova V, Shragina O, Marino SR, Brown NK, Shiina T, Suzuki S, Spierings E, Zhang Q, Yin Y, Morris GP, Hernandez A, Ruiz P, Khor SS, Tokunaga K, Geretz A, Thomas R, Yamamoto F, Mallempati KC, Gangavarapu S, Kanga U, Tyagi S, Marsh SGE, Bultitude WP, Liu X, Cao D, Penning M, Hurley CK, Cesbron A, Mueller C, Mytilineos J, Weimer ET, Bengtsson M, Fischer G, Hansen JA, Chang CJ, Mack SJ, Creary LE, Fernandez-Viña MA. Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Workshop. Hum Immunol. 2019 Apr;80(4):228-236.

16) Faé I, Wenda S, Grill C, Fischer GF. HLA-B*44:138Q: Evidence for a confined deletion and recombination events in an otherwise unaffected HLA-haplotype. HLA. 2019 Feb;93(2-3):89-96

17) Müller C, Wendt J, Rauscher S, Sunder-Plassmann R, Richtig E, Fae I, Fischer G, Okamoto I. Risk Factors of Subsequent Primary Melanomas in Austria. JAMA Dermatol. 2019 Feb 1;155(2):188-195

18) Voorter CEM, Matern B, Tran TH, Fink A, Vidan-Jeras B, Montanic S, Fischer G, Fae I, de Santis D, Whidborne R, Andreani M, Testi M, Groeneweg M, Tilanus MGJ. Full-length extension of HLA allele sequences by HLA allele-specific hemizygous Sanger sequencing (SSBT) Hum Immunol. 2018 Nov;79(11):763-772

19) Wendt J, Mueller C, Rauscher S, Fae I, Fischer G, Okamoto I. Contributions by MC1R Variants to Melanoma Risk in Males and Females. JAMA Dermatol. 2018 Jul 1;154(7):789-795

20) Arnold ML, Bach C, Heinemann FM, Horn PA, Ziemann M, Lachmann N, Mühlbacher A, Dick A, Ender A, Thammanichanond D, Schaub S, Hönger G, Fischer GF, Mytilineos J, Hallensleben M, Hitzler WE, Seidl C, Spriewald BM. Anti-HLA alloantibodies of the IgA isotype in re-transplant candidates part II: Correlation with graft survival. Int J Immunogenet. 2018 Jun;45(3):

21) Koblischke M, Mackroth MS, Schwaiger J, Fae I, Fischer G, Stiasny K, Heinz FX, Aberle JH. Protein structure shapes immunodominance in the CD4 T cell response to yellow fever vaccination. Sci Rep. 2017 Aug 21;7(1):8907.

22) Wenda S, Faé I, Fischer GF.An HLA-B7-specific antibody in an HLA-B*07 positive patient explained by a nonexpressed allele (HLA-B*07:181N). HLA. 2017 Jul;90(1):32-35

23) Wahrmann M, Mühlbacher J, Marinova L, Regele H, Huttary N, Eskandary F, Cohen G, Fischer GF, Parry GC, Gilbert JC, Panicker S, Böhmig GA Effect of the Anti-C1s Humanized Antibody TNT009 and its Parental Mouse Variant TNT003 on HLA Antibody-induced Complement Activation - A Preclinical in Vitro Study. Am J Transplant. 2017 Mar 1

24) Böhmig GA, Fronek J, Slavcev A, Fischer GF, Berlakovich G, Viklicky O Czech-Austrian kidney paired donation: first European cross-border living donor kidney exchange. Transpl Int. 2017 Feb 25

25) Wendt J, Rauscher S, Burgstaller-Muehlbacher S, Fae I, Fischer G, Pehamberger H, Okamoto I.Human Determinants and the Role of Melanocortin-1 Receptor Variants in Melanoma Risk Independent of UV Radiation Exposure. JAMA Dermatol. 2016 Apr 6.

26) Bojic M, Worel N, Sperr WR, Schellongowski P, Wohlfarth P, Schwarzinger I, Mitterbauer-Hohendanner G, Fischer G, Dieckmann KU, Lamm W, Leiner M, Schulenburg A, Mitterbauer M, Greinix HT, Kalhs P, Rabitsch W. Umbilical Cord Blood Transplantation Is a Feasible Rescue Therapeutic Option for Patients Suffering from Graft Failure after Previous Hematopoietic Stem Cell Transplantation. Oncology. 2016;90(3):160-6

27) Müller C, Wendt J, Rauscher S, Burgstaller-Muehlbacher S, Sunder-Plassmann R, Scheurecker C, Richtig E, Fae I, Fischer G, Pehamberger H, Okamoto I Characterization of high risk melanoma patients in Austria. Br J Dermatol. 2016 Jan 22.

28) Schossleitner K, Habertheuer A, Finsterwalder R, Friedl HP, Rauscher S, Gröger M, Kocher A, Wagner C, Wagner SN, Fischer G, Schultz MJ, Wiedemann D, Petzelbauer P.

A Peptide to Reduce Pulmonary Edema in a Rat Model of Lung Transplantation. PLoS One. 2015 Nov 4;10(11

29) Mack SJ, Milius RP, Gifford BD, Sauter J, Hofmann J, Osoegawa K, Robinson J, Groeneweg M, Turenchalk GS, Adai A, Holcomb C, Rozemuller EH, Penning MT, Heuer ML, Wang C, Salit ML, Schmidt AH, Parham PR, Müller C, Hague T, Fischer G, Fernandez-Viňa M, Hollenbach JA, Norman PJ, Maiers M.Minimum information for reporting next generation sequence genotyping (MIRING): Guidelines for reporting HLA and KIR genotyping via next generation sequencing. Hum Immunol. 2015 Dec;76(12):954-62

30) Freimüller C, Stemberger J, Artwohl M, Germeroth L, Witt V, Fischer G, Tischer S, Eiz-Vesper B, Knippertz I, Dörrie J, Schaft N, Lion T, Fritsch G, Geyeregger R.

Selection of adenovirus-specific and Epstein-Barr virus-specific T cells with major histocompatibility class I streptamers under Good Manufacturing Practice (GMP)-compliant conditions. Cytotherapy. 2015 Jul;17(7):989-1007

31) Kitzmüller C, Zulehner N, Roulias A, Briza P, Ferreira F, Faé I, Fischer GF, Bohle B.

Correlation of sensitizing capacity and T-cell recognition within the Bet v 1 family. J Allergy Clin Immunol. 2015 Jul;136(1):151-8.

32) Van Hemelen D, Mahler V, Fischer G, Fae I, Reichl-Leb V, Pickl W, Jutel M, Smolinska S, Ebner C, Bohle B, Jahn-Schmid B.HLA class II peptide tetramers vs allergen-induced proliferation for identification of allergen-specific CD4 T cells. Allergy. 2015 Jan;70(1):49-58

33) Petersdorf EW, Gooley TA, Malkki M, Bacigalupo AP, Cesbron A, Du Toit E, Ehninger G, Egeland T, Fischer GF, Gervais T, Haagenson MD, Horowitz MM, Hsu K, Jindra P, Madrigal A, Oudshoorn M, Ringdén O, Schroeder ML, Spellman SR, Tiercy JM, Velardi A, Witt CS, O'Huigin C, Apps R, Carrington M HLA-C expression levels define permissible mismatches in hematopoietic cell transplantation. International Histocompatibility Working Group in Hematopoietic Cell Transplantation.

Blood. 2014 Dec 18;124

34) Deifl S, Kitzmüller C, Steinberger P, Himly M, Jahn-Schmid B, Fischer GF, Zlabinger GJ, Bohle B. Differential activation of dendritic cells by toll-like receptors causes diverse differentiation of naïve CD4+ T cells from allergic patients. Allergy. 2014 Dec;69(12):1602-9

35) Leitner GC, Faschingbauer M, Wenda S, Weigel G, Fischer G.

Administration of recombinant human granulocyte-colony-stimulating factor does not induce long-lasting detectable epigenetic alterations in healthy donors. Transfusion. 2014 Dec;54(12):3121-6.

36) Schwaiger J, Aberle JH, Stiasny K, Knapp B, Schreiner W, Fae I, Fischer G, Scheinost O, Chmelik V, Heinz FX.Specificities of human CD4+ T cell responses to an inactivated flavivirus vaccine and infection: correlation with structure and epitope prediction. J Virol. 2014 Jul;88(14):7828-42.

37) Geyeregger R, Freimüller C, Stemberger J, Fischer G, Witt V, Fritsch G.

Human AdV-specific T cells: persisting in vitro functionality despite lethal irradiation. Bone Marrow Transplant. 2014 Jul;49(7):934-41.

38) Nunes JM, Buhler S, Roessli D, Sanchez-Mazas A; HLA-net 2013 collaboration The HLA-net GENE[RATE] pipeline for effective HLA data analysis and its application to 145 population samples from Europe and neighbouring areas. Tissue Antigens. 2014 May;83(5):307-23.

39) Geyeregger R, Freimüller C, Stemberger J, Artwohl M, Witt V, Lion T, Fischer G, Lawitschka A, Ritter J, Hummel M, Holter W, Fritsch G, Matthes-Martin S.

First-in-man clinical results with good manufacturing practice (GMP)-compliant polypeptide-expanded adenovirus-specific T cells after haploidentical hematopoietic stem cell transplantation. J Immunother. 2014 May;37(4):245-9.

40) Wendt J, Rauscher S, Burgstaller-Mühlbacher S, Roka F, Fae I, Fischer G, Pehamberger H, Okamoto I.Actinic damage on the back is significantly determined by MC1R variants and previous sun exposure compared with other body sites in a multivariate analysis. Br J Dermatol. 2014 Sep;171(3):622-30.

41) Gabriel C, Furst D, Fae I, Wenda S, Zollikofer C, Mytilineos J und Fischer GF HLA typing by next-generation sequencing - getting closer to reality. 2014. Tissue antigens. 83:2, 65-75.

42) Wenda S, Fae I, Sanchez-Mazas A, Nunes JM, Mayr WR und Fischer GF The distribution of MICA alleles in an Austrian population: evidence for increasing polymorphism. 2013. Human immunology. 74:10, 1295-9.

43) Susal C, Roelen DL, Fischer G, Campos EF, Gerbase-DeLima M, Honger G, Schaub S, Lachmann N, Martorell J und Claas F Algorithms for the determination of unacceptable HLA antigen mismatches in kidney transplant recipients. 2013. Tissue antigens. 82:2, 83-92.

44) Geyeregger R, Freimuller C, Stevanovic S, Stemberger J, Mester G, Dmytrus J, Lion T, Rammensee HG, Fischer G, Eiz-Vesper B, Lawitschka A, Matthes S und Fritsch G Short-term in-vitro expansion improves monitoring and allows affordable generation of virus-specific T-cells against several viruses for a broad clinical application. 2013. PloS one. 8:4, e59592.

45) Mack SJ, Cano P, Hollenbach JA, He J, Hurley CK, Middleton D, Moraes ME, Pereira SE, Kempenich JH, Reed EF, Setterholm M, Smith AG, Tilanus MG, Torres M, Varney MD, Voorter CE, Fischer GF, Fleischhauer K, Goodridge D, Klitz W, Little AM, Maiers M, Marsh SG, Muller CR, Noreen H, Rozemuller EH, Sanchez-Mazas A, Senitzer D, Trachtenberg E und Fernandez-Vina M Common and well-documented HLA alleles: 2012 update to the CWD catalogue. 2013. Tissue antigens. 81:4, 194-203.

46) Arnold ML, Heinemann FM, Horn P, Ziemann M, Lachmann N, Muhlbacher A, Dick A, Ender A, Thammanichanond D, Fischer GF, Schaub S, Hallensleben M, Mytilineos J, Hitzler WE, Seidl C, Doxiadis, II und Spriewald BM 16(th) IHIW: anti-HLA alloantibodies of the of IgA isotype in re-transplant candidates. 2013. International journal of immunogenetics. 40:1, 17-20.

47) Hollenbach JA, Augusto DG, Alaez C, Bubnova L, Fae I, Fischer G, Gonzalez-Galarza FF, Gorodezky C, Karabon L, Kusnierczyk P, Noble J, Rickards O, Roberts C, Schaffer M, Shi L, Tavoularis S, Trachtenberg E, Yao Y und Middleton D 16(th) IHIW: population global distribution of killer immunoglobulin-like receptor (KIR) and ligands. 2013. International journal of immunogenetics. 40:1, 39-45.

48) Wohrl S, Moritz KB, Bracher A, Fischer G, Stingl G und Loewe R A c-kit mutation in exon 18 in familial mastocytosis. 2013. The Journal of investigative dermatology. 133:3, 839-41.

49) Wahrmann M, Hlavin G, Fischer G, Marinova L, Schwaiger E, Horl WH, Zlabinger GJ, Kormoczi GF, Konig F und Bohmig GA Modified solid-phase alloantibody detection for improved crossmatch prediction. 2013. Human immunology. 74:1, 32-40.

50) Bohmig GA, Fidler S, Christiansen FT, Fischer Gund Ferrari P Transnational validation of the Australian algorithm for virtual crossmatch allocation in kidney paired donation. 2013. Human immunology. 74:5, 500-5.

51) Garner-Spitzer E, Wagner A, Paulke-Korinek M, Kollaritsch H, Heinz FX, Redlberger-Fritz M, Stiasny K, Fischer GF, Kundi M und Wiedermann U Tick-borne encephalitis (TBE) and hepatitis B nonresponders feature different immunologic mechanisms in response to TBE and influenza vaccination with involvement of regulatory T and B cells and IL-10. 2013. Journal of immunology. 191:5, 2426-36.

52) Sanchez-Mazas A, Vidan-Jeras B, Nunes JM, Fischer G, Little AM, Bekmane U, Buhler S, Buus S, Claas FH, Dormoy A, Dubois V, Eglite E, Eliaou JF, Gonzalez-Galarza F, Grubic Z, Ivanova M, Lie B, Ligeiro D, Lokki ML, da Silva BM, Martorell J, Mendonca D, Middleton D, Voniatis DP, Papasteriades C, Poli F, Riccio ME, Vlachou MS, Sulcebe G, Tonks S, Nevessignsky MT, Vangenot C, van Walraven AM und Tiercy JM Strategies to work with HLA data in human populations for histocompatibility, clinical transplantation, epidemiology and population genetics: HLA-NET methodological recommendations. 2012. International journal of immunogenetics. 39:6, 459-72; quiz 73-6.

53) Rosenmayr A, Pointner-Prager M, Mitterschiffthaler A, Bozic L, Pelzmann B, Tuchler H, Fae I, Fischer GF, Greinix HT, Peters C, Kalhs P, Krieger O, Linkesch W, Nachbaur D, Urban C, Posch U, Lanzer G, Gabriel C, Schennach H und Mayr WR What are a patient's current chances of finding a matched unrelated donor? Twenty years' central search experience in a small country. 2012. Bone marrow transplantation. 47:2, 172-80.

54) Knapp B, Fischer G, Van Hemelen D, Fae I, Maillere B, Ebner C, Schreiner W, Bohle B und Jahn-Schmid B Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background. 2012. BMC immunology. 13, 43.

55) Karle AC, Oostingh GJ, Mutschlechner S, Ferreira F, Lackner P, Bohle B, Fischer GF, Vogt AB und Duschl A Nitration of the pollen allergen bet v 1.0101 enhances the presentation of bet v 1-derived peptides by HLA-DR on human dendritic cells. 2012. PloS one. 7:2, e31483.

56) Chen KW, Focke-Tejkl M, Blatt K, Kneidinger M, Gieras A, Dall'Antonia F, Fae I, Fischer G, Keller W, Valent P, Valenta R und Vrtala S Carrier-bound nonallergenic Der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients. 2012. Allergy. 67:5, 609-21.

57) Rosenmayr A, Pointner-Prager M, Winkler M, Mitterschiffthaler A, Pelzmann B, Bozic L, Pichler SK, Tuchler H, Fae I und Fischer GThe Austrian Bone Marrow Donor Registry: Providing Patients in Austria with Unrelated Donors for Transplant - a Worldwide Cooperation. 2011. Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie. 38:5, 292-99.

58) Nunes E, Heslop H, Fernandez-Vina M, Taves C, Wagenknecht DR, Eisenbrey AB, Fischer G, Poulton K, Wacker K, Hurley CK, Noreen H und Sacchi N Definitions of histocompatibility typing terms. 2011. Blood. 118:23, e180-3.

59) Nunes E, Heslop H, Fernandez-Vina M, Taves C, Wagenknecht DR, Eisenbrey AB, Fischer G, Poulton K, Wacker K, Hurley CK, Noreen H und Sacchi N Definitions of histocompatibility typing terms: Harmonization of Histocompatibility Typing Terms Working Group. 2011. Human immunology. 72:12, 1214-6.

60) Rosenmayr A, Pointner-Prager M, Mitterschiffthaler A, Bozic L, Pelzmann B, Tuchler H, Fae I, Fischer GF, Greinix HT, Peters C, Kalhs P, Krieger O, Linkesch W, Nachbaur D, Urban C, Posch U, Lanzer G, Gabriel C, Schennach H und Mayr WR What are a patient's current chances of finding a matched unrelated donor? Twenty years' central search experience in a small country. 2012. Bone marrow transplantation. 47:2, 172-80.

61) Schulten V, Nagl B, Scala E, Bernardi ML, Mari A, Ciardiello MA, Lauer I, Scheurer S, Briza P, Jurets A, Ferreira F, Jahn-Schmid B, Fischer GF und Bohle B Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut. 2011. Allergy. 66:8, 1005-13.

62) Boehm A, Walcherberger B, Sperr WR, Wohrer S, Dieckmann K, Rosenmayr A, Pernicka E, Fischer G, Worel N, Mitterbauer G, Schwarzinger I, Mitterbauer M, Haas OA, Lechner K, Hinterberger W, Valent P, Greinix HT, Rabitsch W und Kalhs P.Improved outcome in patients with chronic myelogenous leukemia after allogeneic hematopoietic stem cell transplantation over the past 25 years: a single-center experience.2011. Biol Blood Marrow Transplant. 17:133-40

63) Trembleau S, Hoffmann M, Meyer B, Nell V, Radner H, Zauner W, Hammer J, Aichinger G, Fischer G, Smolen J und Steiner G.Immunodominant T-cell epitopes of hnRNP-A2 associated with disease activity in patients with rheumatoid arthritis.2010. Eur J Immunol. 40:1795-808

64) Nunes JM, Riccio ME, Buhler S, Di D, Currat M, Ries F, Almada AJ, Benhamamouch S, Benitez O, Canossi A, Fadhlaoui-Zid K, Fischer G, Kervaire B, Loiseau P, de Oliveira DC, Papasteriades C, Piancatelli D, Rahal M, Richard L, Romero M, Rousseau J, Spiroski M, Sulcebe G, Middleton D, Tiercy JM und Sanchez-Mazas A.Analysis of the HLA population data (AHPD) submitted to the 15th International Histocompatibility/Immunogenetics Workshop by using the Gene[rate] computer tools accommodating ambiguous data (AHPD project report).2010. Tissue Antigens. 76:18-30

65) Mutschlechner S, Egger M, Briza P, Wallner M, Lackner P, Karle A, Vogt AB, Fischer GF, Bohle B und Ferreira F.Naturally processed T cell-activating peptides of the major birch pollen allergen.2010. J Allergy Clin Immunol. 125:711-8, 718 e1-718 e2

66) Garritsen HS, Fae I, Legath N, Hannig H und Fischer GF.Identification of a novel HLA-DRB3*01 variant, HLA-DRB3*0114, containing a DRB1 sequence motif by micro-temperature gradient gel electrophoresis confirmed by sequence-based typing.2010. Tissue Antigens. 75:185-6

67) Bartel G, Wahrmann M, Regele H, Kikic Z, Fischer G, Druml W, Muhlbacher F und Bohmig GA.Peritransplant immunoadsorption for positive crossmatch deceased donor kidney transplantation.2010. Am J Transplant. 10:2033-42

68) Wahrmann M, Bartel G, Exner M, Regele H, Kormoczi GF, Fischer GF, Bohmig GA. Clinical relevance of preformed C4d-fixing and non-C4d-fixing HLA single antigen reactivity in renal allograft recipients. Transpl Int 2009; 22 (10): 982.

69) Stiegler G, Fischer G, Ramanathan G, Bencur P, Weigel G, Mannhalter C. P-selectin mRNA is maintained in platelet concentrates stored at 4 degrees C. Transfusion 2009; 49 (5): 921.

70) Pfistershammer K, Lawitschka A, Klauser C, Leitner J, Weigl R, Heemskerk MH, Pickl WF, Majdic O, Bohmig GA, Fischer GF, Greinix HT, Steinberger P. Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients. Blood 2009; 114 (11): 2323.

71) Ludajic K, Rosenmayr A, Fae I, Fischer GF, Balavarca Y, Bickeboller H, Kalhs P, Greinix HT. Association of HLA-E polymorphism with the outcome of hematopoietic stem-cell transplantation with unrelated donors. Transplantation 2009; 88 (10): 1227.

72) Ludajic K, Balavarca Y, Bickeboller H, Rosenmayr A, Fischer GF, Fae I, Kalhs P, Pohlreich D, Kouba M, Dobrovolna M, Greinix HT. Minor ABO-mismatches are risk factors for acute graft-versus-host disease in hematopoietic stem cell transplant patients. Biol Blood Marrow Transplant 2009; 15 (11): 1400.

73) Ludajic K, Balavarca Y, Bickeboller H, Rosenmayr A, Fae I, Fischer GF, Kouba M, Pohlreich D, Kalhs P, Greinix HT. KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation. Bone Marrow Transplant 2009; 44 (2): 97.

74) Leb VM, Jahn-Schmid B, Kueng HJ, Schmetterer KG, Haiderer D, Neunkirchner A, Fischer GF, Hartl A, Thalhamer J, Steinberger P, Bohle B, Seed B, Pickl WF. Modulation of allergen-specific T-lymphocyte function by virus-like particles decorated with HLA class II molecules. J Allergy Clin Immunol 2009; 124 (1): 121.

75) Kleinle S, Lang R, Fischer GF, Vierhapper H, Waldhauser F, Fodinger M, Baumgartner-Parzer SM. Duplications of the functional CYP21A2 gene are primarily restricted to Q318X alleles: evidence for a founder effect. J Clin Endocrinol Metab 2009; 94 (10): 3954.

76) Garritsen HS, Fae I, Legath N, Hannig H, Fischer GF. Identification of a novel HLA-DRB3*01 variant, HLA-DRB3*0114, containing a DRB1 sequence motif by micro-temperature gradient gel electrophoresis confirmed by sequence-based typing. Tissue Antigens 2009.

77) Doxiadis GG, de Groot N, Dauber EM, van Eede PH, Fae I, Faner R, Fischer G, Grubic Z, Lardy NM, Mayr W, Palou E, Swelsen W, Stingl K, Doxiadis, II, Bontrop RE. High resolution definition of HLA-DRB haplotypes by a simplified microsatellite typing technique. Tissue Antigens 2009; 74 (6): 486.

78) Ludajic K, Balavarca Y, Bickeboller H, Pohlreich D, Kouba M, Dobrovolna M, Vrana M, Rosenmayr A, Fischer GF, Fae I, Kalhs P, Greinix HT. Impact of HLA-DPB1 allelic and single amino acid mismatches on HSCT. Br J Haematol 2008; 142 (3): 436.

79) Leb VM, Jahn-Schmid B, Schmetterer KG, Kueng HJ, Haiderer D, Neunkirchner A, Fischer GF, Nissler K, Hartl A, Thalhamer J, Bohle B, Seed B, Pickl WF. Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes. J Allergy Clin Immunol 2008; 121 (1): 64.

80) Jahn-Schmid B, Sirven P, Leb V, Pickl WF, Fischer GF, Gadermaier G, Egger M, Ebner C, Ferreira F, Maillere B, Bohle B. Characterization of HLA class II/peptide-TCR interactions of the immunodominant T cell epitope in Art v 1, the major mugwort pollen allergen. J Immunol 2008; 181 (5): 3636.

81) Holler E, Rogler G, Brenmoehl J, Hahn J, Greinix H, Dickinson AM, Socie G, Wolff D, Finke J, Fischer G, Jackson G, Rocha V, Hilgendorf I, Eissner G, Marienhagen J, Andreesen R. The role of genetic variants of NOD2/CARD15, a receptor of the innate immune system, in GvHD and complications following related and unrelated donor haematopoietic stem cell transplantation. Int J Immunogenet 2008; 35 (4-5): 381.

82) Fae I, Rosenmayr A, Mayr WR, Fischer GF. A novel HLA-C allele, Cw*0617. Tissue Antigens 2008; 72 (5): 499.

83) Worel N, Greinix HT, Supper V, Leitner G, Mitterbauer M, Rabitsch W, Fischer G, Rosenmayr A, Hocker P, Kalhs P. Prophylactic red blood cell exchange for prevention of severe immune hemolysis in minor ABO-mismatched allogeneic peripheral blood progenitor cell transplantation after reduced-intensity conditioning. Transfusion 2007; 47 (8): 1494.

84) Vidan-Jeras B, Ambroz N, Fae I, Kemperle I, Fischer G. HLA-B*350802, a novel allele, which has arisen by silent mutation at codon 67. Tissue Antigens 2007; 69 (4): 363.

85) Penn DJ, Oberzaucher E, Grammer K, Fischer G, Soini HA, Wiesler D, Novotny MV, Dixon SJ, Xu Y, Brereton RG. Individual and gender fingerprints in human body odour. J R Soc Interface 2007; 4 (13): 331.

86) Meraner P, Horejsi V, Wolpl A, Fischer GF, Stingl G, Maurer D. Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation. J Immunol 2007; 178 (4): 2262.

87) Leb VM, Jahn-Schmid B, Schmetterer KG, Kueng HJ, Haiderer D, Neunkirchner A, Fischer GF, Nissler K, Hartl A, Thalhamer J, Bohle B, Seed B, Pickl WF. Molecular and functional analysis of the antigen receptor of Art v 1-specific helper T lymphocytes. J Allergy Clin Immunol 2007.

88) Karvunidis T, Jindra P, Fischer G, Venigova P, Dorner A, Koza V. Identification of a novel HLA-DRB1*14 allele, HLA-DRB1*1458, by sequence-based typing. Tissue Antigens 2007; 70 (4): 348.

89) Hoftberger R, Garzuly F, Dienes HP, Grubits J, Rohonyi B, Fischer G, Hanzely Z, Lassmann H, Budka H. Fulminant central nervous system demyelination associated with interferon-{alpha} therapy and hepatitis C virus infection. Mult Scler 2007; 13 (9): 1100.

90) Danzer M, Polin H, Proll J, Hofer K, Fae I, Fischer GF, Gabriel C. High-throughput sequence-based typing strategy for HLA-DRB1 based on real-time polymerase chain reaction. Hum Immunol 2007; 68 (11): 915.

91) Baumgartner-Parzer SM, Fischer G, Vierhapper H. Predisposition for de novo gene aberrations in the offspring of mothers with a duplicated CYP21A2 gene. J Clin Endocrinol Metab 2007; 92 (3): 1164.

92) Vidan-Jeras B, Kunilo S, Fae I, Kandus A, Fischer GF. A novel HLA-B*2730 allele found in a Slovene patient affected with IgA nephropathy. Int J Immunogenet 2006; 33 (5): 371.

93) Mrazek F, Fae I, Ambruzova Z, Raida L, Kriegova E, Indrak K, Fischer GF, Petrek M. A single amino acid exchange shifts the serological reactivity of the novel HLA-B*4442 allele product from HLA-B44 to HLA-B21. Int J Immunogenet 2006; 33 (3): 197.

94) Ludajic K, Fae I, Fischer GF. Characterization of a new HLA-DPB1 allele, DPB1*010103. Tissue Antigens 2006; 67 (3): 255.

95) Holler E, Rogler G, Brenmoehl J, Hahn J, Herfarth H, Greinix H, Dickinson AM, Socie G, Wolff D, Fischer G, Jackson G, Rocha V, Steiner B, Eissner G, Marienhagen J, Schoelmerich J, Andreesen R. Prognostic significance of NOD2/CARD15 variants in HLA-identical sibling hematopoietic stem cell transplantation: effect on long-term outcome is confirmed in 2 independent cohorts and may be modulated by the type of gastrointestinal decontamination. Blood 2006; 107 (10): 4189.

96) Danzer M, Polin H, Fae I, Fischer GF, Gabriel C. Exon 1-4 sequence analysis of a novel HLA-A allele, HLA-A*2458. Tissue Antigens 2006; 68 (2): 177.

97) Seidel MG, Fritsch G, Matthes-Martin S, Lawitschka A, Lion T, Potschger U, Rosenmayr A, Fischer G, Gadner H, Peters C. Antithymocyte globulin pharmacokinetics in pediatric patients after hematopoietic stem cell transplantation. J Pediatr Hematol Oncol 2005; 27 (10): 532.

98) Seidel MG, Fritsch G, Matthes-Martin S, Lawitschka A, Lion T, Potschger U, Rosenmayr A, Fischer G, Gadner H, Peters C. In vitro and in vivo T-cell depletion with myeloablative or reduced-intensity conditioning in pediatric hematopoietic stem cell transplantation. Haematologica 2005; 90 (10): 1405.

99) Mrazek F, Fae I, Ambruzova Z, Raida L, Indrak K, Petrek M, Fischer GF. A novel HLA-B*420502 allele identified by PCR-SSO/SSP routine typing and confirmed by Sequencing-based typing. Tissue Antigens 2005; 65 (3): 275.

100) Jahn-Schmid B, Fischer GF, Bohle B, Fae I, Gadermaier G, Dedic A, Ferreira F, Ebner C. Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 *01. J Allergy Clin Immunol 2005; 115 (2): 399.

101) Greinix HT, Fae I, Schneider B, Rosenmayr A, Mitterschiffthaler A, Pelzmann B, Kalhs P, Lechner K, Mayr WR, Fischer GF. Impact of HLA class I high-resolution mismatches on chronic graft-versus-host disease and survival of patients given hematopoietic stem cell grafts from unrelated donors. Bone Marrow Transplant 2005; 35 (1): 57.

102) Bohle B, Zwolfer B, Fischer GF, Seppala U, Kinaciyan T, Bolwig C, Spangfort MD, Ebner C. Characterization of the human T cell response to antigen 5 from Vespula vulgaris (Ves v 5). Clin Exp Allergy 2005; 35 (3): 367.

103) Voorter CE, Fischer GF, van den Berg-Loonen EM. Identification of a new HLA-C allele, Cw*0316, by sequence-based typing. Tissue Antigens 2004; 63 (5): 484.

104) Loewe R, Kittler H, Fischer G, Fae I, Wolff K, Petzelbauer P. BRAF kinase gene V599E mutation in growing melanocytic lesions. J Invest Dermatol 2004; 123 (4): 733.

105) Fae I, Lau M, Voorter C, Mayr WR, Fischer GF. HLA-B*8102*, a new allele found in an external proficiency testing scheme. Tissue Antigens 2004; 64 (5): 608.

106) Danzer M, Leitner D, Gangl E, Fae I, Fischer GF, Gabriel C. A novel HLA-DRB1*13 allele (DRB1*1357) identified by polymerase chain reaction with sequence-specific primers and direct sequencing. Tissue Antigens 2004; 64 (2): 213.

107) Zettinig G, Tanew A, Fischer G, Mayr W, Dudczak R, Weissel M. Autoimmune diseases in vitiligo: do anti-nuclear antibodies decrease thyroid volume? Clin Exp Immunol 2003; 131 (2): 347.

108) Winter D, Fiebiger E, Meraner P, Auer H, Brna C, Strohal R, Trautinger F, Knobler R, Fischer GF, Stingl G, Maurer D. Definition of TCR epitopes for CTL-mediated attack of cutaneous T cell lymphoma. J Immunol 2003; 171 (5): 2714.

109) Vogelsang H, Panzer S, Mayr WR, Granditsch G, Fischer GF. Distribution of HLA class I alleles differs in celiac disease patients according to age of onset. Dig Dis Sci 2003; 48 (3): 611.

110) Spatz M, Eibl N, Hink S, Wolf HM, Fischer GF, Mayr WR, Schernthaner G, Eibl MM. Impaired primary immune response in type-1 diabetes. Functional impairment at the level of APCs and T-cells. Cell Immunol 2003; 221 (1): 15.

111) Bohle B, Radakovics A, Jahn-Schmid B, Hoffmann-Sommergruber K, Fischer GF, Ebner C. Bet v 1, the major birch pollen allergen, initiates sensitization to Api g 1, the major allergen in celery: evidence at the T cell level. Eur J Immunol 2003; 33 (12): 3303.

112) Worel N, Greinix HT, Keil F, Mitterbauer M, Lechner K, Fischer G, Mayr W, Hocker P, Kalhs P. Severe immune hemolysis after minor ABO-mismatched allogeneic peripheral blood progenitor cell transplantation occurs more frequently after nonmyeloablative than myeloablative conditioning. Transfusion 2002; 42 (10): 1293.

113) Worel N, Biener D, Kalhs P, Mitterbauer M, Keil F, Schulenburg A, Hocker P, Dieckmann K, Fischer G, Rosenmayr A, Linkesch W, Hinterberger W, Lechner K, Greinix HT. Long-term outcome and quality of life of patients who are alive and in complete remission more than two years after allogeneic and syngeneic stem cell transplantation. Bone Marrow Transplant 2002; 30 (9): 619.

114) Tiercy JM, Marsh SG, Schreuder GM, Albert E, Fischer G, Wassmuth R. Guidelines for nomenclature usage in HLA reports: ambiguities and conversion to serotypes. Eur J Immunogenet 2002; 29 (3): 273.

115) Nachbaur D, Eibl B, Kropshofer G, Meister B, Mitterschiffthaler A, Schennach H, Fischer G, Kopp M, Gunsilius E, Gastl G. In vivo T cell depletion with low-dose rabbit antithymocyte globulin results in low transplant-related mortality and low relapse incidence following unrelated hematopoietic stem cell transplantation. J Hematother Stem Cell Res 2002; 11 (4): 731.

116) Jahn-Schmid B, Kelemen P, Himly M, Bohle B, Fischer G, Ferreira F, Ebner C. The T cell response to Art v 1, the major mugwort pollen allergen, is dominated by one epitope. J Immunol 2002; 169 (10): 6005.

117) Eibl N, Spatz M, Fischer GF, Mayr WR, Samstag A, Wolf HM, Schernthaner G, Eibl MM. Impaired primary immune response in type-1 diabetes: results from a controlled vaccination study. Clin Immunol 2002; 103 (3 Pt 1): 249.

118) Stockl J, Majdic O, Fischer G, Maurer D, Knapp W. Monomorphic molecules function as additional recognition structures on haptenated target cells for HLA-A1-restricted, hapten-specific CTL. J Immunol 2001; 167 (5): 2724.

119) Fischer GF, Mayr WR. Molecular genetics of the HLA complex. Wien Klin Wochenschr 2001; 113 (20-21): 814.

120) Fischer GF, Fae I, Mann D, Kriks D, Jager W, Platzer W, Mayr WR, Volc-Platzer B. An HLA class-II allele frequent in Eskimos and Amerindians is found in the Tyrolean Ice Man. Ann Hum Genet 2001; 65 (Pt 4): 363.

121) Worel N, Greinix HT, Schneider B, Kurz M, Rabitsch W, Knobl P, Reiter E, Derfler K, Fischer G, Hinterberger W, Hocker P, Kalhs P. Regeneration of erythropoiesis after related- and unrelated-donor BMT or peripheral blood HPC transplantation: a major ABO mismatch means problems. Transfusion 2000; 40 (5): 543.

122) Worel N, Greinix HT, Schneider B, Kurz M, Rabitsch W, Knobl P, Reiter E, Derfler K, Fischer G, Hinterberger W, Hocker P, Kalhs P. Regeneration of erythropoiesis after related- and unrelated-donor BMT or peripheral blood HPC transplantation: a major ABO mismatch means problems [In Process Citation]. Transfusion 2000; 40 (5): 543.

123) Panzer S, Janisiw M, Fischer G, Jilma B. The platelet alpha2-integrin (GPIa) nucleotide-807 polymorphism is not associated with a risk for maternal-fetal human platelet antigen-5 incompatibility. Ann Hematol 2000; 79 (6): 296.

124) Greinix HT, Volc-Platzer B, Kalhs P, Fischer G, Rosenmayr A, Keil F, Honigsmann H, Knobler RM. Extracorporeal photochemotherapy in the treatment of severe steroid- refractory acute graft-versus-host disease: a pilot study [In Process Citation]. Blood 2000; 96 (7): 2426.

125) Greinix HT, Loidolt H, Rabitsch W, Schulenburg A, Keil F, Mitterbauer M, Laczika K, Lechner K, Dieckmann K, Fischer G, Jager U, Rosenmayr A, Knobl P, Schwarzinger I, Hocker P, Mannhalter C, Hinterberger W, Haas OA, Fonatsch C, Kalhs P. Excellent disease eradication by myeloablative therapy and stem-cell transplantation in patients with acute myelogenous leukemia. Ann Hematol 2000; 79 (4): 206.

126) Fae I, Gleissner B, Kriks D, Leitner D, Fischer GF. Serological and nucleotide sequence analysis of HLA-A*6812. Tissue Antigens 2000; 56 (3): 276.

127) Fae I, Gleissner B, Kriks D, Leitner D, Fischer GF. Serological and nucleotide sequence analysis of HLA-A*6812 [In Process Citation]. Tissue Antigens 2000; 56 (3): 276.

128) Bohle B, Wagner B, Vollmann U, Buck D, Niggemann B, Szepfalusi Z, Fischer G, Scheiner O, Breiteneder H, Ebner C. Characterization of T cell responses to Hev b 3, an allergen associated with latex allergy in spina bifida patients. J Immunol 2000; 164 (8): 4393.

129) Anvari A, Janisiw M, Turel Z, Huber K, Fischer G, Panzer S. Platelet glycoprotein Ia gene dimorphism alpha2-807 in malignant arrhythmia in coronary artery disease. Thromb Res 2000; 98 (4): 281.

130) Reiter E, Greinix HT, Keil F, Brugger S, Rabitsch W, Schulenburg A, Mannhalter C, Schwarzinger I, Worel N, Volc-Platzer B, Fischer G, Dieckmann K, Hinterberger W, Schneider B, Haas OA, Geissler K, Kalhs P. Long-term follow-up of patients after related- and unrelated-donor bone marrow transplantation for chronic myelogenous leukemia. Ann Hematol 1999; 78 (11): 507.

131) Peters C, Matthes-Martin S, Fritsch G, Holter W, Lion T, Witt V, Hocker P, Fischer G, Dieckmann K, Handgretinger R, Klingebiel T, Gadner H. Transplantation of highly purified peripheral blood CD34+ cells from HLA-mismatched parental donors in 14 children: evaluation of early monitoring of engraftment. Leukemia 1999; 13 (12): 2070.

132) Kalhs P, Brugger S, Reiter E, Keil F, Fischer G, Schulenburg A, Rabitsch W, Rosenmayr A, Dieckmann K, Kurz M, Schwarzinger I, Volc-Platzer B, Mannhalter C, Lechner K, Greinix HT. Low transplant-related mortality in patients receiving unrelated donor marrow grafts for leukemia. Bone Marrow Transplant 1999; 23 (8): 753.

133) Groger M, Fischer GF, Wolff K, Petzelbauer P. Immune complexes from vasculitis patients bind to endothelial Fc receptors independent of the allelic polymorphism of FcgammaRIIa. J Invest Dermatol 1999; 113 (1): 56.

134) Fodinger M, Wolfl G, Fischer G, Rasoul-Rockenschaub S, Schmid R, Horl WH, Sunder-Plassmann G. Effect of MTHFR 677C>T on plasma total homocysteine levels in renal graft recipients. Kidney Int 1999; 55 (3): 1072.

135) Drabek J, Bunce M, Fae I, Ambruzova Z, Dunn P, Ross J, Fischer GF. Characterization of a novel HLA-A*24 allele containing an HLA-A*03 sequence motif. Tissue Antigens 1999; 54 (1): 98.

136) Strohal R, Brna C, Mossbacher U, Fischer G, Pehamberger H, Stingl G. First comparative delineation of the T cell receptor repertoire in primary and multiple subsequent/coexisting metastatic melanoma sites. J Invest Dermatol 1998; 111 (6): 1085.

137) Strohal R, Brna C, Mossbacher U, Fischer G, Pehamberger H, Stingl G. First comparative delineation of the T cell receptor repertoire in primary and multiple subsequent/coexisting metastatic melanoma sites [published erratum appears in J Invest Dermatol 1999 Feb;112(2):256]. J Invest Dermatol 1998; 111 (6): 1085.

138) Reiter E, Greinix HT, Mitterbauer G, Fischer G, Keil F, Mannhalter C, Rabitsch W, Schwarzinger I, Worel N, Lechner K, Kalhs P. Graft-versus-host disease following second syngeneic stem cell transplantation for relapsed chronic myeloid leukemia. Ann Hematol 1998; 77 (6): 283.

139) Reiter E, Greinix HT, Brugger S, Keil F, Rabitsch W, Mannhalter C, Schwarzinger I, Hocker P, Fischer G, Dieckmann K, Hinterberger W, Linkesch W, Schneider B, Lechner K, Kalhs P. Long term follow up after allogeneic stem cell transplantation for chronic myelogenous leukemia. Bone Marrow Transplant 1998; 22 Suppl 4: S86.

140) Rabitsch W, Reiter E, Keil F, Malzer R, Leitner G, Fischer G, Dieckman K, Kalhs P, Lechner K, Greinix HT. Experience with allogeneic and syngeneic blood stem cell transplantation in patients with hematological malignancies. Bone Marrow Transplant 1998; 22 Suppl 4: S49.

141) Raber W, Fischer G, Vierhapper H. Consanguinity in question in two patients with congenital adrenal hyperplasia who bear an identical first and last name--second look. Wien Klin Wochenschr 1998; 110 (1): 23.

142) Greinix HT, Reiter E, Schulenburg A, Keil F, Lechner K, Fischer G, Rosenmayr A, Leitner G, Kalhs P. Matched unrelated donor marrow transplantation in patients with advanced acute leukemia. Bone Marrow Transplant 1998; 22 Suppl 4: S53.

143) Greinix HT, Reiter E, Keil F, Fischer G, Lechner K, Dieckmann K, Leitner G, Schulenburg A, Hoecker P, Haas OA, Knoebl P, Mannhalter C, Fonatsch C, Hinterberger W, Kalhs P. Leukemia-free survival and mortality in patients with refractory or relapsed acute leukemia given marrow transplants from sibling and unrelated donors. Bone Marrow Transplant 1998; 21 (7): 673.

144) Friedl-Hajek R, Breiteneder H, Bohle B, Fischer G, Ebner C, Scheiner O. Conserved sequence motifs of CDR3 loops of TCR specific for two major epitopes of the grass pollen allergen PhI p 1. Int Immunol 1998; 10 (11): 1725.

145) Fischer GF, Fae I, Frey E, Mayr WR. HLA-A*02172* adds to the heterogeneity of HLA-A*02 alleles. Tissue Antigens 1998; 51 (3): 312.

146) Reiter E, Keil F, Brugger S, Kalhs P, Rabitsch W, Hinterberger W, Fischer G, Rosenmayr A, Haas O, Volc B, Lechner K, Greinix HT. Excellent long-term survival after allogeneic marrow transplantation in patients with severe aplastic anemia. Bone Marrow Transplant 1997; 19 (12): 1191.

147) Pickl WF, Majdic O, Fischer GF, Petzelbauer P, Fae I, Waclavicek M, Stockl J, Scheinecker C, Vidicki T, Aschauer H, Johnson JP, Knapp W. MUC18/MCAM (CD146), an activation antigen of human T lymphocytes. J Immunol 1997; 158 (5): 2107.

148) Fischer GF, Broer E, Fae I, Leitner D, Mayr WR. Nucleotide sequence analysis of an HLA-B47 variant (HLA-B*4702). Tissue Antigens 1997; 49 (5): 540.

149) Schenk S, Breiteneder H, Susani M, Najafian N, Laffer S, Duchene M, Valenta R, Fischer G, Scheiner O, Kraft D, Ebner C. T cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense). Crossreactivity with group I allergens of different grasses. Adv Exp Med Biol 1996; 409: 141.

150) Maurer D, Fiebiger S, Ebner C, Reininger B, Fischer GF, Wichlas S, Jouvin MH, Schmitt-Egenolf M, Kraft D, Kinet JP, Stingl G. Peripheral blood dendritic cells express Fc epsilon RI as a complex composed of Fc epsilon RI alpha- and Fc epsilon RI gamma-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol 1996; 157 (2): 607.

151) Legler TJ, Kohler M, Mayr WR, Panzer S, Ohto H, Fischer GF. Genotyping of the human platelet antigen systems 1 through 5 by multiplex polymerase chain reaction and ligation-based typing. Transfusion 1996; 36 (5): 426.

152) Greinix HT, Keil F, Brugger SA, Reiter E, Linkesch W, Lechner K, Schneider B, Dieckmann KU, Fischer G, Schwarzinger I, Haas O, Hinterberger W, Mannhalter C, Geissler K, Hocker P, Jager U, Kalhs P. Long-term leukemia-free survival after allogeneic marrow transplantation in patients with acute myelogenous leukemia. Ann Hematol 1996; 72 (2): 53.

153) Fischer GF, Fae I, Moser S, Petrasek M, Bassler HM, Menzel GR, Mayr WR. Ligation based HLA-B*27 typing. Tissue Antigens 1996; 48 (3): 148.

154) Dunky A, Neumuller J, Hubner C, Fischer GF, Bayer PM, Wagner E, Schwartz DW, Mayr WR. HLA-B27 determination using serological methods. A comparison of enzyme immunoassay and a microlymphocytotoxic test with flow cytometry and a molecular biological assay. Rheumatol Int 1996; 16 (3): 95.

155) Breiteneder H, Friedl-Hajek R, Ebner C, Schenk S, Fischer G, Kraft D, Scheiner O. Sequence comparisons of the CDR3 hyper-variable loops of human T cell receptors specific for three major T cell epitopes of the birch pollen allergen Bet v 1. Mol Immunol 1996; 33 (13): 1039.

156) Smrzka OW, Fae I, Stoger R, Kurzbauer R, Fischer GF, Henn T, Weith A, Barlow DP. Conservation of a maternal-specific methylation signal at the human IGF2R locus. Hum Mol Genet 1995; 4 (10): 1945.

157) Schenk S, Breiteneder H, Susani M, Najafian N, Laffer S, Duchene M, Valenta R, Fischer G, Scheiner O, Kraft D, et al. T-cell epitopes of Phl p 1, major pollen allergen of timothy grass (Phleum pratense): evidence for crossreacting and non-crossreacting T- cell epitopes within grass group I allergens. J Allergy Clin Immunol 1995; 96 (6 Pt 1): 986.

158) Panzer S, Fischer G. Neonatal thrombocytopenia in HLA-DR,-DQ,-DO-typed mother due to a rare anti-HPA 1b (PLA2) (Zwb) fetomaternal immunization [letter; comment]. Vox Sang 1995; 68 (4): 258.

159) Panzer S, Auerbach L, Cechova E, Fischer G, Holensteiner A, Kitl EM, Mayr WR, Putz M, Wagenbichler P, Walchshofer S. Maternal alloimmunization against fetal platelet antigens: a prospective study. Br J Haematol 1995; 90 (3): 655.

160) Fischer GF, Fae I, Petrasek M, Moser S. A combination of two distinct in vitro amplification procedures for DNA typing of HLA-DRB and -DQB 1 alleles. Vox Sang 1995; 69 (4): 328.

161) Fischer GF, Fae I, Petrasek M, Haas H, Mayr WR. An HLA-DR11 variant (HLA-DRB1*1115) segregating in a family of Turkish origin. Tissue Antigens 1995; 45 (2): 143.

162) Ebner C, Schenk S, Najafian N, Siemann U, Steiner R, Fischer GW, Hoffmann K, Szepfalusi Z, Scheiner O, Kraft D. Nonallergic individuals recognize the same T cell epitopes of Bet v 1, the major birch pollen allergen, as atopic patients. J Immunol 1995; 154 (4): 1932.

163) Breiteneder H, Scheiner O, Hajek R, Hulla W, Huttinger R, Fischer G, Kraft D, Ebner C. Diversity of TCRAV and TCRBV sequences used by human T-cell clones specific for a minimal epitope of Bet v 1, the major birch pollen allergen. Immunogenetics 1995; 42 (1): 53.

164) Berger J, Bernheimer H, Fae I, Braun A, Roscher A, Molzer B, Fischer G. Association of X-linked adrenoleukodystrophy with HLA DRB1 alleles. Biochem Biophys Res Commun 1995; 216 (2): 447.

165) Schenk S, Hoffmann-Sommergruber K, Breiteneder H, Ferreira F, Fischer G, Scheiner O, Kraft D, Ebner C. Four recombinant isoforms of Cor a 1, the major allergen of hazel pollen, show different reactivities with allergen-specific T-lymphocyte clones. Eur J Biochem 1994; 224 (2): 717.

166) Fischer GF, Pickl WF, Fae I, Anegg B, Milota S, Volc-Platzer B. Association between chronic cutaneous lupus erythematosus and HLA class II alleles. Hum Immunol 1994; 41 (4): 280.

167) Weisman LE, Cruess DF, Fischer GW. Standard versus hyperimmune intravenous immunoglobulin in preventing or treating neonatal bacterial infections. Clin Perinatol 1993; 20 (1): 211.

168) Volc-Platzer B, Anegg B, Milota S, Pickl W, Fischer G. Accumulation of gamma delta T cells in chronic cutaneous lupus erythematosus. J Invest Dermatol 1993; 100 (1): 84S.

169) Pickl WF, Fischer GF, Fae I, Kolarz G, Scherak O. HLA-DR1-positive patients suffering from rheumatoid arthritis are at high risk for developing mucocutaneous side effects upon gold therapy. Hum Immunol 1993; 38 (2): 127.

170) Pickl WF, Fae I, Fischer GF. Detection of established and novel alleles of the HLA-DPB1 locus by PCR- SSO. Vox Sang 1993; 65 (4): 316.

171) Opelz G, Mytilineos J, Scherer S, Dunckley H, Trejaut J, Chapman J, Fischer G, Fae I, Middleton D, Savage D, et al. Analysis of HLA-DR matching in DNA-typed cadaver kidney transplants. Transplantation 1993; 55 (4): 782.

172) Mytilineos J, Scherer S, Dunckley H, Trejaut J, Chapman J, Middleton D, Savage D, Fischer G, Fae I, Bignon JD, et al. DNA typing of 3500 cadaver kidney transplants does not confirm the "DR6 effect". Transplant Proc 1993; 25 (1 Pt 1): 207.

173) Mytilineos J, Scherer S, Dunckley H, Trejaut J, Chapman J, Fischer G, Fae I, Middleton D, Savage D, Bignon JD, et al. DNA HLA-DR typing results of 4000 kidney transplants. Transplantation 1993; 55 (4): 778.

174) Fischer GF, Fae I, Pickl WF. The HLA-DRB6*0201 allele of a pseudogene commonly associated with HLA- DR2 specificities is present in an HLA-DRB1*0101-DRB5*0101 haplotype. Immunogenetics 1993; 37 (4): 285.

175) Mytilineos J, Scherer S, Trejaut J, Dunckley H, Chapman J, Fischer G, Fae I, Middleton D, Savage D, Bignon JD, et al. Analysis of discrepancies between serologic and DNA-RFLP typing for HLA- DR in kidney graft recipients. Transplant Proc 1992; 24 (6): 2478.

176) Maurer D, Fischer GF, Fae I, Majdic O, Stuhlmeier K, Von Jeney N, Holter W, Knapp W. IgM and IgG but not cytokine secretion is restricted to the CD27+ B lymphocyte subset. J Immunol 1992; 148 (12): 3700.

177) Fischer GF, Pickl WF, Fae I, Ebner C, Ferreira F, Breiteneder H, Vikoukal E, Scheiner O, Kraft D. Association between IgE response against Bet v I, the major allergen of birch pollen, and HLA-DRB alleles. Hum Immunol 1992; 33 (4): 259.

178) Fischer GF, Fae I, Pickl WF. Distribution of polymorphic HLA-DR and -DQ alleles as determined by restriction fragment length polymorphism analysis in an Austrian population. Vox Sang 1992; 62 (4): 236.

179) Fischer GF, Fae I, Dub E, Pickl WF. Analysis of the gene polymorphism of ABO blood group specific transferases helps diagnosis of acquired B status. Vox Sang 1992; 62 (2): 113.

180) Dennig D, Lam C, Fischer G, Scharf M, Knapp W. Recombinant human granulocyte-macrophage colony-stimulating factor stimulates superoxide anion and hydrogen peroxide production in human neutrophils. J Hematother 1992; 1 (3): 261.

181) Smrzka OW, Fae I, Pickl WF, Fischer GF. HLA-DRB3 typing by restriction digestion of locus-specific amplified DNA. Tissue Antigens 1991; 37 (5): 205.

182) Pickl WF, Fischer GF, Fae I, Speiser P. [Identification of an old frozen alcohol blood sample using a genetic probe technique]. Wien Klin Wochenschr 1991; 103 (5): 155.

183) Opelz G, Mytilineos J, Scherer S, Dunckley H, Trejaut J, Chapman J, Middleton D, Savage D, Fischer O, Bignon JD, et al. Survival of DNA HLA-DR typed and matched cadaver kidney transplants. The Collaborative Transplant Study. Lancet 1991; 338 (8765): 461.

184) Fischer GF, Pickl WF, Fae I, Pausch V, Speiser P. Elucidation of apparent non-maternity with DNA probes detecting highly polymorphic single locus systems. Vox Sang 1991; 60 (3): 181.

185) Fischer GF, Fae I, Valent P, Pickl WF. [The use of highly polymorphic DNA systems in the demonstration of mixed chimerism following bone marrow transplantation]. Wien Klin Wochenschr 1991; 103 (5): 152.

186) Maurer D, Holter W, Majdic O, Fischer GF, Knapp W. CD27 expression by a distinct subpopulation of human B lymphocytes. Eur J Immunol 1990; 20 (12): 2679.

187) Fischer GF, Majdic O, Gadd S, Knapp W. Signal transduction in lymphocytic and myeloid cells via CD24, a new member of phosphoinositol-anchored membrane molecules. J Immunol 1990; 144 (2): 638.

188) Fischer G, Speiser P. [Assessment of apparent non-maternity using individual specific gene probes]. Wien Klin Wochenschr 1990; 102 (10): 309.

189) Fischer GF, Holter W, Majdic O, Cragoe EJ, Jr., Knapp W. T cell stimulation via CD2 molecules is regularly accompanied by an increase in cytoplasmic pH. Different effects of lectins and CD3 antibodies. J Immunol 1988; 141 (2): 404.

190) Holter W, Fischer GF, Majdic O, Stockinger H, Knapp W. T cell stimulation via the erythrocyte receptor. Synergism between monoclonal antibodies and phorbol myristate acetate without changes of free cytoplasmic Ca++ levels. J Exp Med 1986; 163 (3): 654.

Extended Abstracts, Letters

1) Tiercy JM, Fischer G, Setterholm M. Quality control for registry HLA data. Tissue Antigens 2007; 69 Suppl 1: 13.

2) Fischer G. Immunogenetic selection of donors for haematopoietic stem cell transplantation: an approach. Transpl Immunol 2002; 10 (2-3): 223.

3) Fischer G, Kreuzer D, Beer U, Gleissner B, Wasilewski K, Fae I. The sixth quality control exercise of the Central European tissue typing laboratories. Bone Marrow Transplant 1998; 22 Suppl 4: S14.

4) Fischer GF. Molecular genetics of HLA. Vox Sang 2000; 78 (Suppl 2): 261.

5) Panzer S & Fischer G: Neonatal thrombocytopenia in HLA-DR,-DQ,-DP-typed mother due to a rare anti-HPA 1b (PLA2) (Zwb) fetomaternal immunization

Vox Sang. 68: 258 1995

6) Mytilineos J, Scherer S, Trejaut J, Dunckley H, Chapman J, Fischer G, Faé I, Middleton D, Savage D, Bignon JD, Bensa JC, Noreen H, Albert E, Schwarz V, Albrecht G & Opelz G: Analysis of discrepancies between serologic and DNA-RFLP typing for HLA- DR in kidney graft recipients

Transplantation Proc. 24:2478-2479, 1992

7) Opelz G, Mytilineos J, Scherer S, Dunckley H, Trejaut J, Chapman J, Middleton D, Savage D, Fischer GF, Bignon JD, Bensa JC, Albert E, & Noreen H, for the Collaborative Study : DNA typing: an important step forward, Transplant International in press

8) Opelz G, Scherer S, Mytilineos J, Dunckley H, Trejaut J, Chapman J, Middleton D, Savage D, Fischer GF, Bignon JD, Bensa JC, Albert E & Noreen H, for the Collaborative Transplant Study: Analysis of HLA matching in renal transplantation based on DNA class II typing. in HLA 1991. Tsuji et al. (eds.), Oxford University Press 1992

9) Mytilineos J, Scherer S, Dunckley H, Trejaut J, Chapman J, Middleton D, Savage D, Fischer G, Faé I, Bignon JD, Bensa JC, Albrecht G, Schwarz V & Opelz G: DNA typing of 3500 cadaver kidney transplants does not confirm the "DR6 effect". Transplant Proc. 25:207-209 1992

10) Fischer G& Speiser P: Abklärung einer scheinbaren Nichtmutterschaft mittels individualspezifischer GensondenWien. klin. Wochensch. 102: 309 1990

11) Knapp W, GF Fischer , Holter W, Cragoe jr. EJ & Majdic O: Inhibition of the Na+/proton antiporter with the amiloride analogue 5-(N-methyl-N-isobutyl)amiloride (MIA) leads to superinduction of T cell proliferation induced via the alternate (CD2) pathway, Ann. N. Y. Acad. Sci. 546:216 1989

12) Fischer GF, Kreuzer D, Beer U, Gleißner B, Wasilewski K & Faé I: The sixth Quality Control Exercise of the Central European tissue typing laboratories. Bone Marrow Transplant. (Suppl 4): 14-16 1998

13) Rabitsch W, Reiter E, Keil F, Malzer R, Leitner G, Fischer G, Dieckmann K, Kalhs P, Lechner K & Greinix H T: Experience with allogeneic and syngeneic blood stem cell transplantation in patients with hematological malignancies. Bone Marrow Transplant. (Suppl 4): 49-51 1998

14) Greinix H T, Reiter E, Schulenburg A, Keil F, Lechner K, Fischer G, Rosenmayr A, Leitner G & Kalhs P: Matched unrelated donor marrow transplantation in patients with advanced acute leukemia. Bone Marrow Transplant. (Suppl 4): 53-55 1998

15) Reiter E, Greinix H T, Brugger S, Keil F, Rabitsch W, Mannhalter C, Schwarzinger I, Hoecker P, Fischer G, Dieckmann K, Hinterberger W, Linkesch W, Schneider W, Lechner K & Kalhs P:Long term follow up after allogeneic stem cell transplantation for chronic myelogenous leukemia. Bone Marrow Transplant. 22(Suppl 4): 86-88 1998

Books

1) Knapp, W, Majdic O, H. Stockinger, Köller U, Bettelheim P, Fischer GF, Skrobal A, & Lutz D: Analytik und Manipulation humaner Zellen mit monoklonalen Antikörpern. in: Biotechnologie von heute. L. Janszky ed., OMIKK Verlag Budapest, P 551987

2) Knapp, W, Holter W, Majdic O, Stockinger H, Fischer GF, Skrobal A: Membrane structures involved in human T cell activation. in: Lectures and Symposia 14 th Int. Cancer Congr. Vol 2: Molecular Biology and Differentiation of Cancer Cells. Lapis/Eckhardt Eds., Karger Verlag, Basel/Academiai Kladò Budapest pp 267-274 1987

3) Fischer GF, Ingrid Faé & Elisabeth Gschwantler: Flow cytometrische Analyse verschiedener Rh-Phänotypen. in: Festschrift zum 65. Geburtstag Prof. Arndt Hanser, Fresenius 1988 pp 7-12

4) Fischer GF, Majdic O & Knapp W: Molecular cytology of granulocyte activation. in: Genotypic, Phenotypic and Functional Aspects of Hematopoiesis. Grignani F., Martelli M.F. and Mason D, eds, Raven Press, N.Y. pp 81-85 1987

5) Fischer GF, Majdic O & Knapp W: Cytological analysis of functional alterations in granulocytes in: New Frontiers in Cytology. K. Goerttler et al., eds., pp 32-36 1988

6) Speiser P unter Mitarbeit von Vilma Pausch, Winter P, Schwartz D, Hajek-Rosenmayer A & Fischer GF: Molekularbiologische Methoden in der Blutgruppenserologie. in: Laboratoriumsdiagnostik.Herausgegeben von Erwin Deutsch, Georg Geyer und Rudolf Wenger (eds.) Schering 1990

7) Fischer G& Mayr WR: Das HLA System. in Transfusionsmedizin. Herausgegeben von Christian Mueller-Eckhardt und Volker Kiefel (eds) Springer 2010

ARin Ingrid Fae, MSc

wissenschaftliche Mitarbeiterin

Medizinische Universität Wien
Universitätsklinik für Transfusionsmedizin und Zelltherapie
Währinger Gürtel 18–20, 1090 Wien

Telefon: +43 (0)1 40400-53320
Pager (nur intern verfügbar): 81-6108
E-Mail: ingrid.fae@meduniwien.ac.at

Speiser P, Fischer G, Pickl WF, Fae I, Pausch V, Kribitz M. [Usefulness and cogency of gene probes in paternity questions (Personal experiences: 1989/90]. Wien Klin Wochenschr. 1990;102:673-676.

Fischer GF, Fae I, Valent P, Pickl WF. [The use of highly polymorphic DNA systems in the demonstration of mixed chimerism following bone marrow transplantation]. Wien Klin Wochenschr. 1991;103:152-154.

Fischer GF, Pickl WF, Fae I, Pausch V, Speiser P. Elucidation of apparent non-maternity with DNA probes detecting highly polymorphic single locus systems. Vox Sang. 1991;60:181-183.

Pickl WF, Fischer GF, Fae I, Speiser P. [Identification of an old frozen alcohol blood sample using a genetic probe technique]. Wien Klin Wochenschr. 1991;103:155-157.

Smrzka OW, Fae I, Pickl WF, Fischer GF. HLA-DRB3 typing by restriction digestion of locus-specific amplified DNA. Tissue Antigens. 1991;37:205-210.

Fischer GF, Fae I, Dub E, Pickl WF. Analysis of the gene polymorphism of ABO blood group specific transferases helps diagnosis of acquired B status. Vox Sang. 1992;62:113-116.

Fischer GF, Fae I, Pickl WF. Distribution of polymorphic HLA-DR and -DQ alleles as determined by restriction fragment length polymorphism analysis in an Austrian population. Vox Sang. 1992;62:236-241.

Fischer GF, Pickl WF, Fae I, et al. Association between IgE response against Bet v I, the major allergen of birch pollen, and HLA-DRB alleles. Hum Immunol. 1992;33:259-265.

Maurer D, Fischer GF, Fae I, et al. IgM and IgG but not cytokine secretion is restricted to the CD27+ B lymphocyte subset. J Immunol. 1992;148:3700-3705.

Mytilineos J, Scherer S, Trejaut J, et al. Analysis of discrepancies between serologic and DNA-RFLP typing for HLA-DR in kidney graft recipients. Transplant Proc. 1992;24:2478-2479.

Fischer GF, Fae I, Pickl WF. The HLA-DRB6*0201 allele of a pseudogene commonly associated with HLA-DR2 specificities is present in an HLA-DRB1*0101-DRB5*0101 haplotype. Immunogenetics. 1993;37:285-287.

Mytilineos J, Scherer S, Dunckley H, et al. DNA HLA-DR typing results of 4000 kidney transplants. Transplantation. 1993;55:778-781.

Mytilineos J, Scherer S, Dunckley H, et al. DNA typing of 3500 cadaver kidney transplants does not confirm the "DR6 effect". Transplant Proc. 1993;25:207-209.

Opelz G, Mytilineos J, Scherer S, et al. Analysis of HLA-DR matching in DNA-typed cadaver kidney transplants. Transplantation. 1993;55:782-785.

Pickl WF, Fae I, Fischer GF. Detection of established and novel alleles of the HLA-DPB1 locus by PCR-SSO. Vox Sang. 1993;65:316-319.

Pickl WF, Fischer GF, Fae I, Kolarz G, Scherak O. HLA-DR1-positive patients suffering from rheumatoid arthritis are at high risk for developing mucocutaneous side effects upon gold therapy. Hum Immunol. 1993;38:127-131.

Pickl WF, Majdic O, Fae I, Reuschel R, Holter W, Knapp W. The soluble pool of beta 2-microglobulin free HLA class I alpha-chains. Qualitative and quantitative characterization. J Immunol. 1993;151:2613-2622.

Berger J, Molzer B, Fae I, Bernheimer H. X-linked adrenoleukodystrophy (ALD): a novel mutation of the ALD gene in 6 members of a family presenting with 5 different phenotypes. Biochem Biophys Res Commun. 1994;205:1638-1643.

Fischer GF, Pickl WF, Fae I, Anegg B, Milota S, Volc-Platzer B. Association between chronic cutaneous lupus erythematosus and HLA class II alleles. Hum Immunol. 1994;41:280-284.

Moser R, Fae I, Neumeister A, Pober M, Mutz I, Panzer S. Neonatal allo-immune thrombocytopenia due to fetomaternal HPA-1 incompatibility of a homozygous HPA-1a mother and a homozygous HPA-1b father. A case report. Eur J Pediatr. 1994;153:95-97.

Berger J, Bernheimer H, Fae I, et al. Association of X-linked adrenoleukodystrophy with HLA DRB1 alleles. Biochem Biophys Res Commun. 1995;216:447-451.

Fischer GF, Fae I, Petrasek M, Haas H, Mayr WR. An HLA-DR11 variant (HLA-DRB1*1115) segregating in a family of Turkish origin. Tissue Antigens. 1995;45:143-144.

Fischer GF, Fae I, Petrasek M, Moser S. A combination of two distinct in vitro amplification procedures for DNA typing of HLA-DRB and -DQB 1 alleles. Vox Sang. 1995;69:328-335.

Smrzka OW, Fae I, Stoger R, et al. Conservation of a maternal-specific methylation signal at the human IGF2R locus. Hum Mol Genet. 1995;4:1945-1952.

Berger J, Gmach M, Fae I, Molzer B, Bernheimer H. A new polymorphism of arylsulfatase A within the coding region. Hum Genet. 1996;98:348-350.

Fischer GF, Fae I, Moser S, et al. Ligation based HLA-B*27 typing. Tissue Antigens. 1996;48:148-152.

Fischer GF, Broer E, Fae I, Leitner D, Mayr WR. Nucleotide sequence analysis of an HLA-B47 variant (HLA-B*4702). Tissue Antigens. 1997;49:540-542.

Pickl WF, Majdic O, Fischer GF, et al. MUC18/MCAM (CD146), an activation antigen of human T lymphocytes. J Immunol. 1997;158:2107-2115.

Fischer G, Kreuzer D, Beer U, Gleissner B, Wasilewski K, Fae I. The sixth quality control exercise of the Central European tissue typing laboratories. Bone Marrow Transplant. 1998;22 Suppl 4:S14-16.

Fischer GF, Fae I, Frey E, Mayr WR. HLA-A*02172* adds to the heterogeneity of HLA-A*02 alleles. Tissue Antigens. 1998;51:312-314.

Drabek J, Bunce M, Fae I, et al. Characterization of a novel HLA-A*24 allele containing an HLA-A*03 sequence motif. Tissue Antigens. 1999;54:98-101.

Fae I, Gleissner B, Kriks D, Leitner D, Fischer GF. Serological and nucleotide sequence analysis of HLA-A*6812. Tissue Antigens. 2000;56:276-278.

Fischer GF, Fae I, Mann D, et al. An HLA class-II allele frequent in Eskimos and Amerindians is found in the Tyrolean Ice Man. Ann Hum Genet. 2001;65:363-369.

Danzer M, Leitner D, Gangl E, Fae I, Fischer GF, Gabriel C. A novel HLA-DRB1*13 allele (DRB1*1357) identified by polymerase chain reaction with sequence-specific primers and direct sequencing. Tissue Antigens. 2004;64:213-214.

Fae I, Lau M, Voorter C, Mayr WR, Fischer GF. HLA-B*8102*, a new allele found in an external proficiency testing scheme. Tissue Antigens. 2004;64:608-610.

Loewe R, Kittler H, Fischer G, Fae I, Wolff K, Petzelbauer P. BRAF kinase gene V599E mutation in growing melanocytic lesions. J Invest Dermatol. 2004;123:733-736.

Greinix HT, Fae I, Schneider B, et al. Impact of HLA class I high-resolution mismatches on chronic graft-versus-host disease and survival of patients given hematopoietic stem cell grafts from unrelated donors. Bone Marrow Transplant. 2005;35:57-62.

Jahn-Schmid B, Fischer GF, Bohle B, et al. Antigen presentation of the immunodominant T-cell epitope of the major mugwort pollen allergen, Art v 1, is associated with the expression of HLA-DRB1 *01. J Allergy Clin Immunol. 2005;115:399-404.

Mrazek F, Fae I, Ambruzova Z, et al. A novel HLA-B*420502 allele identified by PCR-SSO/SSP routine typing and confirmed by Sequencing-based typing. Tissue Antigens. 2005;65:275-277.

Danzer M, Polin H, Fae I, Fischer GF, Gabriel C. Exon 1-4 sequence analysis of a novel HLA-A allele, HLA-A*2458. Tissue Antigens. 2006;68:177-178.

Ludajic K, Fae I, Fischer GF. Characterization of a new HLA-DPB1 allele, DPB1*010103. Tissue Antigens. 2006;67:255-256.

Mrazek F, Fae I, Ambruzova Z, et al. A single amino acid exchange shifts the serological reactivity of the novel HLA-B*4442 allele product from HLA-B44 to HLA-B21. Int J Immunogenet. 2006;33:197-200.

Vidan-Jeras B, Kunilo S, Fae I, Kandus A, Fischer GF. A novel HLA-B*2730 allele found in a Slovene patient affected with IgA nephropathy. Int J Immunogenet. 2006;33:371-373.

Danzer M, Polin H, Proll J, et al. High-throughput sequence-based typing strategy for HLA-DRB1 based on real-time polymerase chain reaction. Hum Immunol. 2007;68:915-917.

Vidan-Jeras B, Ambroz N, Fae I, Kemperle I, Fischer G. HLA-B*350802, a novel allele, which has arisen by silent mutation at codon 67. Tissue Antigens. 2007;69:363.

Ludajic K, Balavarca Y, Bickeboller H, et al. Impact of HLA-DPB1 allelic and single amino acid mismatches on HSCT. Br J Haematol. 2008.

Faé I, Rosenmayr A, Mayr WR, Fischer GF. A novel HLA-C allele, Cw*0617. Tissue Antigens. 2008 Nov;72(5):499-500.

Ludajic K, Balavarca Y, Bickeböller H, Rosenmayr A, Fae I, Fischer GF, Kouba M, Pohlreich D, Kalhs P, Greinix HT. KIR genes and KIR ligands affect occurrence of acute GVHD after unrelated, 12/12 HLA matched, hematopoietic stem cell transplantation. Bone Marrow Transplant. 2009 Jul;44(2):97-103.

Doxiadis GG, de Groot N, Dauber EM, van Eede PH, Fae I, Faner R, Fischer G, Grubic Z, Lardy NM, Mayr W, Palou E, Swelsen W, Stingl K, Doxiadis II, Bontrop RE. High resolution definition of HLA-DRB haplotypes by a simplified microsatellite typing technique. Tissue Antigens. 2009 Dec;74(6):486-93

Ludajic K, Balavarca Y, Bickeböller H, Rosenmayr A, Fischer GF, Faé I, Kalhs P, Pohlreich D, Kouba M, Dobrovolna M, Greinix HT. Minor ABO-mismatches are risk factors for acute graft-versus-host disease in hematopoietic stem cell transplant patients. Biol Blood Marrow Transplant. 2009 Nov;15(11):1400-6.

Ludajic K, Rosenmayr A, Faé I, Fischer GF, Balavarca Y, Bickeböller H, Kalhs P, Greinix HT. Association of HLA-E polymorphism with the outcome of hematopoietic stem-cell transplantation with unrelated donors. Transplantation. 2009 Nov 27;88(10):1227-8.

Garritsen HS, Fae I, Legath N, Hannig H, Fischer GF. Identification of a novel HLA-DRB3*01 variant, HLA-DRB3*0114, containing a DRB1 sequence motif by micro-temperature gradient gel electrophoresis confirmed by sequence-based typing. Tissue Antigens. 2010 Feb;75(2):185-6.

Rosenmayr A, Pointner-Prager M, Mitterschiffthaler A, Bozic L, Pelzmann B, Tüchler H, Fae I, Fischer GF, Greinix HT, Peters Ch, Kalhs P, Krieger O, Linkesch W, Nachbaur D, Urban Ch, Posch U, Lanzer G, Gabriel Ch, Schennach H, Mayr WR. What are a patient's current chances of finding a matched unrelated donor? Twenty years' central search experience in a small country. Bone Marrow Transplant. 2012 Feb;47(2):172-80

Chen KW, Focke-Tejkl M, Blatt K, Kneidinger M, Gieras A, Dall'Antonia F, Faé I, Fischer G, Keller W, Valent P, Valenta R, Vrtala S. Carrier-bound nonallergenic Der p 2 peptides induce IgG antibodies blocking allergen-induced basophil activation in allergic patients. Allergy. 2012 May;67(5):609-21.

Rosenmayr A, Pointner-Prager M, Winkler M, Mitterschiffthaler A, Pelzmann B, Bozic L, Pichler SK, Tüchler H, Fae I, Fischer G. The Austrian Bone Marrow Donor Registry: Providing Patients in Austria with Unrelated Donors for Transplant - a Worldwide Cooperation. Transfus Med Hemother. 2011 Oct;38(5):292-299.

Association of HLA-DR1 with the allergic response to the major mugwort pollen allergen: molecular background. Knapp B, Fischer G, Van Hemelen D, Fae I, Maillere B, Ebner C, Schreiner W, Bohle B, Jahn-Schmid B. BMC Immunol. 2012 Aug 8;13:43.

Gonzalez-Galarza FF, Mack SJ, Hollenbach J, Fernandez-Vina M, Setterholm M, Kempenich J, Marsh SG, Jones AR, Middleton D; HLA Rare Allele Consortium. 16(th) IHIW: extending the number of resources and bioinformatics analysis for the investigation of HLA rare alleles. Int J Immunogenet. 2013 Feb;40(1):60-5.

Hollenbach JA, Augusto DG, Alaez C, Bubnova L, Fae I, Fischer G, Gonzalez-Galarza FF, Gorodezky C, Karabon L, Kusnierczyk P, Noble J, Rickards O, Roberts C, Schaffer M, Shi L, Tavoularis S, Trachtenberg E, Yao Y, Middleton D. 16(th) IHIW: population global distribution of killer immunoglobulin-like receptor (KIR) and ligands. Int J Immunogenet. 2013 Feb;40(1):39-45.

Wenda S, Faé I, Sanchez-Mazas A, Nunes JM, Mayr WR, Fischer GF. The distribution of MICA alleles in an Austrian population: evidence for increasing polymorphism. Hum Immunol. 2013 Oct;74(10):1295-9.

Gabriel C, Fürst D, Faé I, Wenda S, Zollikofer C, Mytilineos J, Fischer GF. HLA typing by next-generation sequencing - getting closer to reality. Tissue Antigens. 2014 Feb;83(2):65-75.

Schwaiger J, Aberle JH, Stiasny K, Knapp B, Schreiner W, Fae I, Fischer G, Scheinost O, Chmelik V, Heinz FX. Specificities of human CD4+ T cell responses to an inactivated flavivirus vaccine and infection: correlation with structure and epitope prediction. J Virol. 2014 Jul;88(14):7828-42

Wendt J, Rauscher S, Burgstaller-Mühlbacher S, Roka F, Fae I, Fischer G, Pehamberger H, Okamoto I. Actinic damage on the back is significantly determined by MC1R variants and previous sun exposure compared with other body sites in a multivariate analysis. Br J Dermatol. 2014 Sep;171(3):622-30.

Van Hemelen D, Mahler V, Fischer G, Fae I, Reichl-Leb V, Pickl W, Jutel M, Smolinska S, Ebner C, Bohle B, Jahn-Schmid B. HLA class II peptide tetramers vs allergen-induced proliferation for identification of allergen-specific CD4 T cells. Allergy. 2015 Jan;70(1):49-58.

Kitzmüller C, Zulehner N, Roulias A, Briza P, Ferreira F, Faé I, Fischer GF, Bohle B. Correlation of sensitizing capacity and T-cell recognition within the Bet v 1 family. J Allergy Clin Immunol. 2015 Jul;136(1):151-8.

Wendt J, Rauscher S, Burgstaller-Muehlbacher S, Fae I, Fischer G, Pehamberger H, Okamoto I. Human Determinants and the Role of Melanocortin-1 Receptor Variants in Melanoma Risk Independent of UV Radiation Exposure. JAMA Dermatol. 2016 Jul 1;152(7):776-82.

Müller C, Wendt J, Rauscher S, Burgstaller-Muehlbacher S, Sunder-Plassmann R, Scheurecker C, Richtig E, Fae I, Fischer G, Pehamberger H, Okamoto I. Characterization of patients at high risk of melanoma in Austria. Br J Dermatol. 2016 Jun;174(6):1308-17.

Koblischke M, Mackroth MS, Schwaiger J, Fae I, Fischer G, Stiasny K, Heinz FX, Aberle JH. Protein structure shapes immunodominance in the CD4 T cell response to yellow fever vaccination. Sci Rep. 2017 Aug 21;7(1):8907

Wenda S, Faé I, Fischer GF. An HLA-B7-specific antibody in an HLA-B*07 positive patient explained by a nonexpressed allele (HLA-B*07:181N). HLA. 2017 Jul;90(1):32-35.

Voorter CEM, Matern B, Tran TH, Fink A, Vidan-Jeras B, Montanic S, Fischer G, Fae I, de Santis D, Whidborne R, Andreani M, Testi M, Groeneweg M, Tilanus MGJ. Full-length extension of HLA allele sequences by HLA allele-specific hemizygous Sanger sequencing (SSBT). Hum Immunol. 2018 Nov;79(11):763-772.

Wendt J, Mueller C, Rauscher S, Fae I, Fischer G, Okamoto I. Contributions by MC1R Variants to Melanoma Risk in Males and Females. JAMA Dermatol. 2018 Jul 1;154(7):789-795

Askar M, Madbouly A, Zhrebker L, Willis A, Kennedy S, Padros K, Rodriguez MB, Bach C, Spriewald B, Ameen R, Shemmari SA, Tarassi K, Tsirogianni A, Hamdy N, Mossallam G, Hönger G, Spinnler R, Fischer G, Fae I, Charlton R, Dunk A, Vayntrub TA, Halagan M, Osoegawa K, Fernández-Viña M. HLA Haplotypes In 250 Families: The Baylor Laboratory Results And A Perspective On A Core NGS Testing Model For The 17th International HLA And Immunogenetics Workshop. Hum Immunol. 2019 Nov;80(11):897-905.

Schischlik F, Jäger R, Rosebrock F, Hug E, Schuster M, Holly R, Fuchs E, Milosevic Feenstra JD, Bogner E, Gisslinger B, Schalling M, Rumi E, Pietra D, Fischer G, Faé I, Vulliard L, Menche J, Haferlach T, Meggendorfer M, Stengel A, Bock C, Cazzola M, Gisslinger H, Kralovics R. Mutational landscape of the transcriptome offers putative targets for immunotherapy of myeloproliferative neoplasms. Blood. 2019 Jul 11;134(2):199-210.

Müller C, Wendt J, Rauscher S, Sunder-Plassmann R, Richtig E, Fae I, Fischer G, Okamoto I. Risk Factors of Subsequent Primary Melanomas in Austria. JAMA Dermatol. 2019 Feb 1;155(2):188-195.

Faé I, Wenda S, Grill C, Fischer GF HLA-B*44:138Q: Evidence for a confined deletion and recombination events in an otherwise unaffected HLA-haplotype. HLA. 2019 Feb;93(2-3):89-96

Villazala-Merino S, Rodriguez-Dominguez A, Stanek V, Campion NJ, Gattinger P, Hofer G, Froeschl R, Fae I, Lupinek C, Vrtala S, Breiteneder H, Keller W, Perkmann T, Nakamura R, Pickl WF, Valenta R, Eckl-Dorna J, Niederberger V. Allergen-specific IgE levels and the ability of IgE-allergen complexes to cross-link determine the extent of CD23-mediated T-cell activation. J Allergy Clin Immunol. 2020 Mar;145(3):958-967

Koblischke M, Spitzer FS, Florian DM, Aberle SW, Malafa S, Fae I, Cassaniti I, Jungbauer C, Knapp B, Laferl H, Fischer G, Baldanti F, Stiasny K, Heinz FX, Aberle JH. CD4 T Cell Determinants in West Nile Virus Disease and Asymptomatic Infection. Front Immunol. 2020 Jan 23;11:16.

Doberer K, Bond G, Kläger J, Regele H, Strassl R, Reindl-Schwaighofer R, Scheriau G, Wahrmann M, Kikić Ž, Faé I, Fischer G, Böhmig GA, Eskandary F. Immunoadsorption Combined with Membrane Filtration to Counteract Early Treatment-Refractory Antibody-Mediated Rejection. Blood Purif. 2020 Mar 19:1-10

Ondrej Viklicky, Sebastian Krivanec , Hana Vavrinova , Gabriela Berlakovich, Tomas Marada, Janka Slatinska, Tereza Neradova, Renata Zamecnikova, Andreas Salat, Michael Hofmann, Gottfried Fischer, Antonij Slavcev, Pavel Chromy, Rainer Oberbauer, Tomas Pantoflicek , Sabine Wenda, Elisabeth Lehner, Ingrid Fae, Paolo Ferrari, Jiri Fronek , Georg A Böhmig  Crossing borders to facilitate live donor kidney transplantation: the Czech-Austrian kidney paired donation program - a retrospective study Transpl Int 2020 Oct;33(10):1199-1210.  

Benedikt Agerer, Maximilian Koblischke, Venugopal Gudipati, Luis Fernando Montaño-Gutierrez,  Mark Smyth,  Alexandra Popa, Jakob-Wendelin Genger, Lukas Endler, David M Florian, Vanessa Mühlgrabner, Marianne Graninger, Stephan W Aberle, Anna-Maria Husa, Lisa Ellen Shaw, Alexander Lercher, Pia Gattinger, Ricard Torralba-Gombau, Doris Trapin, Thomas Penz, Daniele Barreca, Ingrid Fae, Sabine Wenda, Marianna Traugott, Gernot Walder, Winfried F Pickl , Volker Thiel , Franz Allerberger, Hannes Stockinger, Elisabeth Puchhammer-Stöckl, Wolfgang Weninger, Gottfried Fischer, Wolfgang Hoepler, Erich Pawelka, Alexander Zoufaly, Rudolf Valenta, Christoph Bock, Wolfgang Paster, René Geyeregger, Matthias Farlik, Florian Halbritter, Johannes B Huppa, Judith H Aberle, Andreas Bergthaler; SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses, Sci Immunol 2021 Mar 4;6(57):eabg6461

Bernhard Kratzer, Doris Trapin, Paul Ettel, Ulrike Körmöczi, Arno Rottal, Friedrich Tuppy, Melanie Feichter, Pia Gattinger, Kristina Borochova, Yulia Dorofeeva, Inna Tulaeva, Milena Weber, Katharina Grabmeier-Pfistershammer, Peter A Tauber, Marika Gerdov, Bernhard Mühl, Thomas Perkmann, Ingrid Fae, Sabine Wenda, Harald Führer, Rainer Henning, Rudolf Valenta, Winfried F Pickl; Immunological imprint of COVID-19 on human peripheral blood leukocyte populations Allergy 2021 Mar;76(3):751-765.

Anita Borski, Alexander Kainz, Nicolas Kozakowski, Heinz Regele, Johannes Kläger, Robert Strassl, Gottfried Fischer, Ingrid Faé, Sabine Wenda, Željko Kikić, Gregor Bond, Roman Reindl-Schwaighofer, Katharina A Mayer, Michael Eder, Markus Wahrmann, Susanne Haindl, Konstantin Doberer, Georg A Böhmig, Farsad Eskandary Early Estimated Glomerular Filtration Rate Trajectories After Kidney Transplant Biopsy as a Surrogate Endpoint for Graft Survival in Late Antibody-Mediated Rejection; Front Med (Lausanne). 2022 Apr 21;9:817127

Accordion Liste Text

Berufserfahrung

  • Seit 1984 Universitätsklinik für Blutgruppenserologie und Transfusionsmedizin
  • Erythrozytenlabor
  • HLA Antikörperlabor
  • Zellkultur für MLC Testung und Etablierung von EBV Zelllinien
  • Ab 1987 maßgebliche Mitarbeit am Aufbau des HLA-DNA Typisierungslabors
  • Erfahrung in SSP, SSO, SBT NGS, qPCR Techniken

Berufsausbildung

  • 2016 ESHI (European Specialisation in Histocompatibility and Immunogenetics) Honorary Diploma
  • 2008-2010 Masterlehrgang Biomedizinische Analytik, FH Campus Wien, Wien, Österreich
  • Masterarbeit: Bestimmung von ILT Polymorphismen, Bestimmung des ILT5-ILT8 Polymorphismus in Familienstudien
  • 1980-1983 Schule für den medizin-technischen Laboratoriumsdienst der Stadt Wien, Wien, Österreich

Mitgliedschaften

  • Seit 1988 DGI-Mitglied
  • Seit 1995 EFI-Mitglied
  • 2012-2020 Mitglied European Federation for Immunogenetics (EFI) Standard Committee
  • Bis 2012  Mitglied – Fachkompetenz Immungenetik der dt. Gesellschaft für Immungenetik
  • (DGI)
  • 2012-2014 Beisitzer im Board der DGI
  • 2008-2012 Mitglied im Fortbildungskomitee der DGI
  • Ab 1998 EFI Inspektor für Labore in und außerhalb Europas
  • Ab 2013 EFI Commisioner für Labore in Region 5 (Österreich, Tschechien, Polen, Russland, Slowenien, Kasachstan)

Tätigkeiten

  • Technical Supervisor für HLA Antikörperlabor und HLA-DNA Labor
    • Stellv. QM an der Blutgruppenserologie
  • Etablierung HLA Next Generation Sequenzierung
  • Etablierung Sequenzierung nicht-klassischer HLA Gene
  • Etablierung non-HLA Antikörpertestung
  • Etablierung dd-cf DNA im post-transplant Monitoring
  • Seit 1998 CET-EPT Ringversuchsprovider für HLA Labore in Österreich, Tschechien, Polen, Ungarn, Slowenien, Kroatien, Serbien, Bulgarien, Rumänien, Armenien, Russland, Kasachstan, Slowakei

Betreuung von Bachelorarbeiten an der FH Campus Wien

  • 2008 Mohammed Helal Uddin: A DNA based comparison of the distribution of the                 HLA Class I alleles in HIV+ patients and HIV- controls, to test whether specific HLA alleles are associated with alterations in the risk off HIV seropositivity
  • 2011 Anton Klotz: Etablierung allelspezifischer Primer für HLA-C
  • 2012 Nina Benitschka: C4d-FACS- Crossmatch
  • 2012 Elisabeth Krieger: Etablierung von sequenzspeifischen Primern für HLA-B
  • 2013 Vanessa Mayr: Die Verteilung bekannter und neuer HLA-G Allele in einer österreichischen Population
  • 2014 Anita Thu Huong Nguyen: HLA-G Whole Gene Sequencing mittels Next Generation Sequencing am Ion Torrent Personal Genom Machine
  • 2016 Cherilyn Cikan: GAMMA-Type Testing: A Retrospective Cohort-Study of AML Patients
  • 2009-2021 Vorlesung über Sequenziertechniken für Masterlehrgang Biomedizinische Analytik, FH Campus Wien, Wien, Österreich

Preise

  • 1995 MTA Preis der DGI für besondere Leistungen im Bereich HLA

ARin Sabine Wenda, MSc

wissenschaftliche Mitarbeiterin

Medizinische Universität Wien
Universitätsklinik für Transfusionsmedizin und Zelltherapie
Währinger Gürtel 18–20, 1090 Wien

Telefon: +43 (0)1 40400-53200
Telefon: +43 (0)1 40400-53320
E-Mail: sabine.wenda@meduniwien.ac.at

Early Estimated Glomerular Filtration Rate Trajectories After Kidney Transplant Biopsy as a Surrogate Endpoint for Graft Survival in Late Antibody-Mediated Rejection. Borski A, Kainz A, Kozakowski N, Regele H, Kläger J, Strassl R, Fischer G, Faé I, Wenda S, Kikić Ž, Bond G, Reindl-Schwaighofer R, Mayer KA, Eder M, Wahrmann M, Haindl S, Doberer K, Böhmig GA, Eskandary F. Front Med (Lausanne). 2022 Apr 21;9:817127. doi: 10.3389/fmed.2022.817127. eCollection 2022. PMID: 35530045

Effects of Reduced-Dose Anti-Human T-Lymphocyte Globulin on Overall and Donor-Specific T-Cell Repertoire Reconstitution in Sensitized Kidney Transplant Recipients. Aschauer C, Jelencsics K, Hu K, Gregorich M, Reindl-Schwaighofer R, Wenda S, Wekerle T, Heinzel A, Oberbauer R. Front Immunol. 2022 Feb 25;13:843452. doi: 10.3389/fimmu.2022.843452. eCollection 2022. PMID: 35281040

SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8+ T cell responses. Agerer B, Koblischke M, Gudipati V, Montaño-Gutierrez LF, Smyth M, Popa A, Genger JW, Endler L, Florian DM, Mühlgrabner V, Graninger M, Aberle SW, Husa AM, Shaw LE, Lercher A, Gattinger P, Torralba-Gombau R, Trapin D, Penz T, Barreca D, Fae I, Wenda S, Traugott M, Walder G, Pickl WF, Thiel V, Allerberger F, Stockinger H, Puchhammer-Stöckl E, Weninger W, Fischer G, Hoepler W, Pawelka E, Zoufaly A, Valenta R, Bock C, Paster W, Geyeregger R, Farlik M, Halbritter F, Huppa JB, Aberle JH, Bergthaler A. Sci Immunol. 2021 Mar 4;6(57):eabg6461. doi: 10.1126/sciimmunol.abg6461. PMID: 33664060

Concordance with established tests and reproducibility of results obtained with a new single antigen chip array for HLA antibody detection (HISTO SPOT® HLA AB). Launhardt K, Lefevre V, Souplet V, Prantl L, Marget M, Hovoricova B, Wenda S, Olivier C. J Immunol Methods. 2021 Apr;491:112971. doi: 10.1016/j.jim.2021.112971. Epub 2021 Feb 4. PMID: 33549571

Immunological imprint of COVID-19 on human peripheral blood leukocyte populations Kratzer B, Trapin D, Ettel P, Körmöczi U, Rottal A, Tuppy F, Feichter M, Gattinger P, Borochova K, Dorofeeva Y, Tulaeva I, Weber M, Grabmeier-Pfistershammer K, Tauber PA, Gerdov M, Mühl B, Perkmann T, Fae I, Wenda S, Führer H, Henning R, Valenta R, Pickl WF. Allergy. 2021 Mar;76(3):751-765. doi: 10.1111/all.14647. Epub 2020 Nov 22.

Donor-specific HLA antibodies after fresh decellularized vs cryopreserved native allograft implantation. Coti I, Wenda S, Andreeva A, Kocher A, Laufer G, Fischer G, Andreas M. HLA. 2020 Nov;96(5):580-588. doi: 10.1111/tan.14077. Epub 2020 Oct 13. PMID: 32975376 Free PMC article.

Crossing borders to facilitate live donor kidney transplantation: the Czech-Austrian kidney paired donation program - a retrospective study. Viklicky O, Krivanec S, Vavrinova H, Berlakovich G, Marada T, Slatinska J, Neradova T, Zamecnikova R, Salat A, Hofmann M, Fischer G, Slavcev A, Chromy P, Oberbauer R, Pantoflicek T, Wenda S, Lehner E, Fae I, Ferrari P, Fronek J, Böhmig GA. Transpl Int. 2020 Oct;33(10):1199-1210. doi: 10.1111/tri.13668. Epub 2020 Jun 23. PMID: 32491249

Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Workshop. Osoegawa K, Vayntrub TA, Wenda S, De Santis D, Barsakis K, Ivanova M, Hsu S, Barone J, Holdsworth R, Diviney M, Askar M, Willis A, Railton D, Laflin S, Gendzekhadze K, Oki A, Sacchi N, Mazzocco M, Andreani M, Ameen R, Stavropoulos-Giokas C, Dinou A, Torres M, Dos Santos Francisco R, Serra-Pages C, Goodridge D, Balladares S, Bettinotti MP, Iglehart B, Kashi Z, Martin R, Saw CL, Ragoussis J, Downing J, Navarrete C, Chong W, Saito K, Petrek M, Tokic S, Padros K, Beatriz Rodriguez M, Zakharova V, Shragina O, Marino SR, Brown NK, Shiina T, Suzuki S, Spierings E, Zhang Q, Yin Y, Morris GP, Hernandez A, Ruiz P, Khor SS, Tokunaga K, Geretz A, Thomas R, Yamamoto F, Mallempati KC, Gangavarapu S, Kanga U, Tyagi S, Marsh SGE, Bultitude WP, Liu X, Cao D, Penning M, Hurley CK, Cesbron A, Mueller C, Mytilineos J, Weimer ET, Bengtsson M, Fischer G, Hansen JA, Chang CJ, Mack SJ, Creary LE, Fernandez-Viña MA. Hum Immunol. 2019 Apr;80(4):228-236. doi: 10.1016/j.humimm.2019.01.009. Epub 2019 Feb 6. Review.

HLA-B*44:138Q: Evidence for a confined deletion and recombination events in an otherwise unaffected HLA-haplotype. Faé I, Wenda S, Grill C, Fischer GF. HLA. 2019 Feb;93(2-3):89-96. doi: 10.1111/tan.13439. Epub 2019 Jan 6.

An HLA-B7-specific antibody in an HLA-B*07 positive patient explained by a nonexpressed allele (HLA-B*07:181N). Wenda S, Faé I, Fischer GF. HLA. 2017 Jul;90(1):32-35. doi: 10.1111/tan.13045. Epub 2017 Apr 17

Standardized genotyping of HLA STR by CE as surrogate for HLA class I and II markers and for identification of HLA identical siblings. Dauber EM, Wenda S, Schwartz-Jungl EM, Glock B, Mayr WR. Electrophoresis. 2016 Mar;37(5-6):849-59

Sequence-based definition of eight short tandem repeat loci located within the HLA-region in an Austrian population. Dauber EM, Wenda S, Schwartz-Jungl EM, Glock B, Mayr WR. Forensic Sci Int Genet. 2015 Jan;14:168-73.

Resolution of HLA-B*44:02:01G, -DRB1*14:01:01G and -DQB1*03:01:01G reveals a high allelic variability among 12 European populations. Vidan-Jeras B, Buhler S, Dubois V, Grubic Z, Ivanova M, Jaatinen T, Ligeiro D, Lokki ML, Papasteriades C, Poli F, Spyropoulou-Vlachou M, Tordai A, Viken MK, Wenda S, Nunes JM, Sanchez-Mazas A, Tiercy JM. Tissue Antigens. 2014 Nov;84(5):459-64.

Administration of recombinant human granulocyte-colony-stimulating factor does not induce long-lasting detectable epigenetic alterations in healthy donors. Leitner GC, Faschingbauer M, Wenda S, Weigel G, Fischer G. Transfusion. 2014 Dec;54(12):3121-6.

HLA typing by next-generation sequencing - getting closer to reality. Gabriel C, Fürst D, Faé I, Wenda S, Zollikofer C, Mytilineos J, Fischer GF. Tissue Antigens. 2014 Feb;83(2):65-75.

The distribution of MICA alleles in an Austrian population: evidence for increasing polymorphism. Wenda S, Faé I, Sanchez-Mazas A, Nunes JM, Mayr WR, Fischer GF. Hum Immunol. 2013 Oct;74(10):1295-9

ACTBP2 (alias ACTBP8) is localized on chromosome 6 (band 6q14). Wenda S, Dauber EM, Schwartz DW, Jungbauer C, Weirich V, Wegener R, Mayr WR. Forensic Sci Int. 2005 Mar 10;148(2-3):207-9.

C2_4_4 microheterogeneity and HLA Class I. Wenda S, Dauber EM, Stadlbacher S, Glock B, Fischer M, Körmöczi GF, Mayr WR. Tissue Antigens. 2003 Jun;61(6):484-6.

The tetranucleotide repeat polymorphism C2_4_4: population data and linkage disequilibria with HLA class I. Stadlbacher S, Dauber EM, Wenda S, Glock B, Hafner M, Körmöczi GF, Mayr WR. Immunobiology. 2003;207(2):137-40.

Berufserfahrung und Ausbildung

  • seit 1989 - Universitätsklinik für Blutgruppenserologie und Transfusionsmedizin
  • seit 2006 - Molekulare Diagnostik DNA-Labor
  • 1998-2001 & 1989-1994 - HLA-Antikörperlabor
  • 2001-2006 - Labor für Hämogenetik
  • 2010-2012 - Masterlehrgang Biomedizinische Analytik, FH Campus Wien, Wien, Österreich: Masterarbeit: Verteilung der MICA (Major Histocompatibility Complex Class I Chain-Related Gene A) Allele innerhalb einer österreichischen Bevölkerung und deren Kopplungsungleichgewicht zu HLA-B Allelen
  • 2016 - ESHI (European Specialisation in Histocompatibility and Immunogenetics) Honorary Diploma

Mitgliedschaften

  • seit 2021 - Mitglied European Federation for Immunogenetics (EFI) Standard Committee
  • seit 2006 - DGI-Mitglied (dt. Gesellschaft für Immungenetik)
  • seit 2006 - EFI-Mitglied (European Federation for Immunogenetics)
  • bis 2012 - Mitglied Fachkompetenz Immungenetik der dt. Ges. für Immungenetik (DGI)

Tätigkeiten

  • Technical Supervisor – HLA-Antikörper Labor und HLA-DNA Labor
  • Kidney Paired Donation Programm (Österreich-Tschechien-Israel)
  • Etablierung HLA Next Generation Sequenzierung
  • Etablierung MICA/MICB Sequenzierung
  • Etablierung non-HLA Antikörpertestung
  • Etablierung dd-cf DNA im post-transplant Monitoring
  • CET- EPT Ringversuchsprovider
  • Stellv. Qualitätsmanagement
  • 2019-2021 - Lehre Sequenziertechnik Masterlehrgang Biomedizinische Analytik, FH Campus Wien
  • seit 2013 - Betreuung Bachelorarbeiten Biomedizinische Analytik

Labor für Transplantationsimmunologie

Das Labor für Transplantationsimmunnologie widmet sich den Bereich der HLA Antikörperdiagnostik und Analyse sowie der Gewebetypisierung und molekularen Diagnostiken bei immunologischen Fragestellungen.

  • Immungenetik
  • immunrelevante Polymorphismen der DNA
  • HLA-Loss
  • nicht klassische HLA-Antigene (HLA-E, F, G)
  • MICA
  • MICB
  • rekombinante Familienkonstellationen
  • neue Allele
  • seltene Allele
  • Haplotypendiagnostik
  • serologische Epitope
  • Abstoßungsdiagnostik
  • non-HLA Antikörper

und viele weitere Untersuchungen.


Klinische Fragestellungen und Laborleistungen

Molekulare Diagnostik HLA-Labor

  • HLA Typisierungen - HLA-Klasse I und HLA-Klasse II Loci, niedrige bzw. hohe Auflösung
  • KIR Typisierungen - Polygenie von KIR2DL1-5, KIR2DS1-5, KIR3DL1-3, KIR3DS1, KIR2DP1, KIR3DP1; KIR-Liganden, KIR-B-content, KIR-Haplotypen
  • T-cell receptor excision circles (TRECs) - Quantifizierung von zirkulären T-Zellrezeptor-Segmenten
  • CCR5 - Chemokinrezeptorpolymorphismus
  • Donor-derived cell free DNA (dd-cfDNA) - Chimärismus von transplantiertem Gewebe im Blutplasma

Hier finden Sie eine Übersicht zu den Laborleistungen geordnet nach Indikation/klinischer Fragestellung inkl. den passenden Zuweisungen für den Bereich HLA Diagnostik.

Untersuchung von potentiellen Empfänger:innen, verwandten und unverwandten Spender:innen, Nabelschnurblutspender:innen

Probenmaterial: 7 ml EDTA Blut, Einsendung jederzeit möglich

Untersuchung von Empfänger:innen und Spender:innen, verwandt und unverwandt

Probenmaterial: 7 ml EDTA Blut, Einsendung jederzeit möglich

Untersuchung von Empfänger:innen und Spender:innen

Probenmaterial: 7 ml EDTA Blut, Einsendung jederzeit möglich

Zöliakie, Narkolepsie, Bird-Shot Retinopathie, Mb. Bechterew, Mb. Behcet, u.a.

Probenmaterial: 7 ml EDTA Blut, Einsendung jederzeit möglich

Abacavirhypersensibilität, Carbamazepinhypersensibilität

Probenmaterial: 7 ml EDTA Blut, Einsendung jederzeit möglich

Bestimmung der Restthymusaktivität

Probenmaterial: 7 ml EDTA Blut, Einsendung jederzeit möglich

Bestimmung der donor-derived cell free (ddcf) DNA

Probenmaterial: 7 ml K2-EDTA Röhrchen mit TrenngelEinsendung jederzeit möglich, die Blutprobe muss innerhalb einer Stunde nach der Abnahme an der Leitstelle 4i einlangen!

Für Befundinterpretationen bzw. Rückfragen wenden Sie sich bitte an den ärztlichen Laborleiter.

HLA-Antikörperlabor

  • Lymphozytotoxizitätstest (complement-dependent cytotoxicity) - HLA-Antikörpernachweis an vitalen Zellen mittels Komplement-abhängiger Lyse
  • Mikropartikeltest (Luminex Analyse)
  • Antikörpernachweis an mit HLA-Molekülen beladenen Mikropartikeln
  • Flowzytometrie - Antikörpernachweis an vitalen Zellen mittels Fluoreszenz

Aufnahme in die Warteliste, solide Organtransplantation

Probenmaterial: laut Einsendeschein

Spender:innenevaluierung, solide Organtransplantation

Probenmaterial: laut Einsendeschein

Crossmatch virtuell – zellulär, solide Organtransplantation

Probenmaterial: laut Einsendeschein

Bestimmung von donor-spezifischen Antikörpern, solide Organtransplantation

Probenmaterial: laut Einsendeschein

Spender:innenausschluss aufgrund von HLA-Antikörpern

Probenmaterial: laut Einsendeschein

Spender:innenausschluss aufgrund von HLA-Antikörpern

Probenmaterial: laut Einsendeschein

Heparinblut bei Raumtemperatur transportieren, siehe HLA Laborzuweisung!